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MetabolomicsCharacterization of active peptides derived from three leeches and comparison of their anti-thrombotic mechanisms using the tail vein thrombosis model in mice and metabonomics

BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real mater...

2024-01-18 | MTBLS9306 | MetaboLights
MetabolomicsUntargeted UHPLC-MS metabolomics reveals candidate regional markers in commercial wines from Southern Brazil
Rio Grande do Sul is Brazil’s leading wine-producing state and hosts the majority of the country’s Geographical Indications. This study hypothesizes that commercial Merlot and Chardonnay wines from different Geographical Indications and municipalities of Rio Grande do Sul exhibit distinct chemical f...
2026-06-15 | MTBLS14574 | MetaboLights
ProteomicsA targeted proteomics strategy to identify markers of resistance in pea
Ascochyta blight, caused by Peyronellaea pinodes, is one of major diseases of pea worldwide. Only low levels of resistance are available in pea cultivars. Quantitative Trait Loci associated with resistance to this disease have been identified, but the resistant genes underlying these QTLs are unknow...
ORGANISM(S): Pisum sativum (Garden pea) 
2022-02-22 | PXD009351 | Pride
Markers Resistance Ascochyta blight Targeted proteomics Pea 
ProteomicsProteomics data analysis for the identification of proteins and derived proteotypic peptides to be used as drought tolerance markers in Quercus ilex
Drought is considered one of the main causes of mortality of holm oak (Quercus ilex) upon seedling plantations in reforestation programs. Although Q. ilex shows high adaptability to extreme climate conditions prevailing in Southern Spain, the genetic variability inherent to this species could be ass...
ORGANISM(S): Quercus ilex (Holly oak) 
2023-03-11 | PXD023782 | Pride
Targeted post-acquisition proteomics Peptides markers Quercus ilex Drought tolerance 
MetabolomicsMetabolomic Profile of Diet-Induced Obesity Mice in Response to Human and Small Humanin-like Peptide 2 Treatment

INTRODUCTION: The mitochondrial-derived peptides (MDPs) are a novel group of natural occurring peptides that have important signaling functions and biological activity. Both humanin and small-humanin-like peptide 2 (SHLP2) have been reported to act as insulin sensitizers and modu...

2019-06-21 | MTBLS159 | MetaboLights
ProteomicsAnalysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers
We have performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from knee and/or hip OA cartilage, which may serve as disease markers.
ORGANISM(S): Homo sapiens (Human) 
2019-07-30 | PXD011800 | Pride
Osteoarthritis Cartilage Peptidome 
ProteomicsPancreatic ductal adenocarcinoma (PDAC) ubiquitination profiling reveals specific prognostic and theranostic markers.
The project was aimed at identifying diGlycine (diGly) conjugated peptides obtained from sixty PDACs' patients' derived xenografs (PDXs) then to identify potential diGLy profiles that could be used as prognosis markers of the aggressiveness of the tumour and overall survival of patients as well as t...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD030011 | Pride
Theranostic markers. Ubiquitinome Digly peptide profiling Prognostic markers Lc-msms Pdac 
TranscriptomicsResponse of peripheral blood mononuclear cells to west nile virus (E, NS2a) and type 1 diabetogenic antigens (GAD65, ZnT8) derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 3 healthy donors. The cells ...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72372 | biostudies-arrayexpress
TranscriptomicsResponse of fresh or frozen peripheral blood mononuclear cells from 1 healthy donor to influenza virus derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 1 healthy donor. The fresh c...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72375 | biostudies-arrayexpress
TranscriptomicsResponse of peripheral blood mononuclear cells from patients with allergy to cat and silver birch wood derived antigenic peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 2 donors with allergy. The c...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72373 | biostudies-arrayexpress
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