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ProteomicsPeptidylarginine Deiminase inhibition abolishes the production of large extracellular vesicles from Giardia intestinalis, affecting host-pathogen interactions by hindering adhesion to host cells
Giardia intestinalis is a microaerophilic protozoan that is an important etiologic agent of diarrhea worldwide. There is evidence that under diverse conditions, the parasite is capable of shedding extracellular vesicles (EVs) which modulate the physiopathology of giardiasis. Here we describe new fea...
ORGANISM(S): Giardia 
2020-09-21 | PXD018460 | Pride
Host-pathogen interaction Giardia intestinalis Cannabidiol (cbd) Peptidylarginine deiminase inhibitor Extracellular vesicles 
ProteomicsA cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation
Deregulation of the peptidylarginine deiminase PADI4 promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. Genetic or pharmacological PADI4 inhibition is therapeutically efficacious in mice but no clinically relevant inhibitors exist to date. PADI4 additi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD048807 | Pride
Deiminase Cyclic-peptide Modulator Padi4 
TranscriptomicsExamination of the role of peptidylarginine deiminase 2 (PAD2) in gene expression in MCF-7 breast cancer cells
To investigate the potential role of peptidylarginine deiminase 2 (PAD2) in gene expression, we created stable shRNA scrambled control and PAD2 knockdown MCF-7 breast cancer cell lines. After validating the specific knockdown of PAD2 at the mRNA and protein level, we utilized an Agilent microarray ...
ORGANISM(S): Homo sapiens 
2012-04-06 | E-GEOD-37087 | biostudies-arrayexpress
UnknownA Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma.
Not available
S-EPMC7335350 | biostudies-literature
UnknownPeptidylarginine Deiminase Inhibitor Suppresses Neutrophil Extracellular Trap Formation and MPO-ANCA Production.
Not available
S-EPMC4896908 | biostudies-literature
UnknownSuppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Not available
S-EPMC3119113 | biostudies-literature
UnknownA cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation.
Not available
S-EPMC11555231 | biostudies-literature
UnknownPeptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.
Not available
S-EPMC5144008 | biostudies-literature
UnknownPeptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer.
Not available
S-EPMC11297914 | biostudies-literature
UnknownPeptidylarginine deiminase 4 deficiency alleviates hypoxia/reoxygenation-induced cardiomyocyte injury.
Not available
S-EPMC12422421 | biostudies-literature
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