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TranscriptomicsChanges in mouse cognition and hippocampal gene expression observed in a mild physical- and blast-traumatic brain injury
Warfare has long been associated with traumatic brain injury (TBI) in militarized zones. Common forms of TBI can be caused by a physical insult to the head-brain or by the effects of a high velocity blast shock wave generated by the detonation of an explosive device. While both forms of trauma are d...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-44625 | biostudies-arrayexpress
TranscriptomicsExendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
Traumatic brain injury (TBI) is a global problem reaching near epidemic numbers that manifests clinically with cognitive problems that decades later may result in dementias like Alzheimer’s disease (AD). Presently, little can be done to prevent ensuing neurological dysfunctions by pharmacological me...
ORGANISM(S): Mus musculus 
2012-10-17 | E-GEOD-41345 | biostudies-arrayexpress
ProteomicsCombined Peptide array screen and proximity labeling proteomics fine map C/EBPa protein interactions
The pioneering transcription factor C/EBPα coordinates cell fate and cell differentiation. The structure of C/EBPα comprises intrinsically disordered regions, multiple short linear motifs, and extensive post-translational side chain modifications (PTM), reflecting its modularity and functional plast...
ORGANISM(S): Homo sapiens (Human) 
2021-07-12 | PXD022903 | Pride
Ptm Cebpa Bioid Peptide pulldowns 
ProteomicsA universal peptide matrix interactomics approach to disclose motif dependent protein binding
Protein-protein interactions (PPIs) mediated by intrinsically disordered regions (IDRs) are often based on short linear motifs (SLiM). SLiMs are implicated in signal transduction and gene regulation, yet remain technically laborious and notoriously challenging to study. Here, we present an optimized...
ORGANISM(S): Homo sapiens (Human) 
2021-08-11 | PXD027265 | Pride
Prisma Ptm Peptide interactomics 
TranscriptomicsResveratrol Diet Aging (Heart, Liver, Muscle and Fat Tissue)
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others ha...
ORGANISM(S): Mus musculus 
2008-08-04 | E-GEOD-11845 | biostudies-arrayexpress
UnknownSafety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial.
Not available
S-EPMC8115997 | biostudies-literature
UnknownIntegration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.
Not available
S-EPMC4724186 | biostudies-literature
UnknownUse of whole genome sequencing to determine genetic basis of suspected mitochondrial disorders: cohort study.
Not available
S-EPMC8565085 | biostudies-literature
UnknownThe functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium.
Not available
S-EPMC10827654 | biostudies-literature
UnknownEffect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC9857647 | biostudies-literature
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