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UnknownDNA vaccine encoding human papillomavirus antigens flanked by a signal peptide and a KDEL sequence induces a potent therapeutic antitumor effect.
Not available
S-EPMC5403354 | biostudies-literature
TranscriptomicsPI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer
Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors and selective PI3Kα inhibitors are in clinical development. The activity of these agents, however, is not homogenous and only a fraction of patients bearing PIK3CA-mutant ER-posi...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-64033 | biostudies-arrayexpress
ProteomicsXiphophorus Hybrid Liver Mitochondria PRM
Hybrids between species contain a mixture of two divergent proteomes, the combination of which may lead to dysfunctional protein-protein interactions. We performed an integrative study on hybrids between the swordtail fishes Xiphophorus malinche and Xiphophorus birchmanni, and found that the combina...
ORGANISM(S): Xiphophorus malinche x Xiphophorus birchmanni 
2024-05-23 | PXD046217 | Pride
Liver Fish Mitochondria Prm Complex Allele 
UnknownUnderstanding and reframing clinical errors through just culture: protocol for the DECIDE mixed-methods study in Spanish healthcare and community contexts.
Not available
S-EPMC12548628 | biostudies-literature
TranscriptomicsThe cellular origin and malignant transformation of Waldenström's Macroglobulinemia [copy number variation]
Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation from IgM MGUS remain undetermined. Here, we undertook an integrative phenotypic, molecular and genomi...
ORGANISM(S): Homo sapiens 
2015-05-06 | E-GEOD-61650 | biostudies-arrayexpress
TranscriptomicsThe cellular origin and malignant transformation of Waldenström's Macroglobulinemia [gene expression]
Although information on the molecular pathogenesis of Waldenström’s Macroglobulinemia (WM) has greatly improved in recent years, the exact cellular origin and the mechanisms behind WM transformation from IgM MGUS remain undetermined. Here, we undertook an integrative phenotypic, molecular and genomi...
ORGANISM(S): Homo sapiens 
2015-05-05 | E-GEOD-61597 | biostudies-arrayexpress
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we demonstrate that dimeric IgA, but not the same antib...
ORGANISM(S): Homo Sapiens 
2026-06-12 | PXD044426 | panorama
UnknownThe Origin, Epidemiology, and Phylodynamics of Human Immunodeficiency Virus Type 1 CRF47_BF.
Not available
S-EPMC9172993 | biostudies-literature
UnknownCARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3.
Not available
S-EPMC9279682 | biostudies-literature
UnknownIdentification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia.
Not available
S-EPMC12686701 | biostudies-literature
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