Sort   by:  
 Page size 
ProteomicsHuman tumor pericyte protein mass spectrometry
Proteomics analysis can reveal the differences of protein expression between mural cells (known as pericytes) from normal adjacent tissues (NPC) and tumors (TPC), implying the effectiveness of pericyte to tumor.
ORGANISM(S): Homo sapiens (Human) 
2021-08-24 | PXD026963 | Pride
Pericyte Human 
TranscriptomicsMicroarray data from control and pericyte-deficient mouse brain microvascular transcriptomes
The blood-brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment of the central nervous system (CNS). The main physical barrier is found in the CNS endothelial cell, and depends on continuous complexes of ...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-15892 | biostudies-arrayexpress
TranscriptomicsPericyte-fibroblast transition promotes tumor growth and metastasis
Vascular pericytes, an important cellular component, in the tumor microenvironment, are often associated with tumor vasculatures and their functions in cancer invasion and metastasis are poorly understood. Here we show that PDGF-BB induces pericyte fibroblast transition (designated as PFT), which si...
ORGANISM(S): Mus musculus 
2016-08-24 | E-GEOD-85955 | biostudies-arrayexpress
ProteomicsProteomic characterization of extracellular matrix (ECM) produced by human fibroblast activation protein (FAP)-positive pericyte-like cells and glioma cells
Fibroblast activation protein (FAP) is upregulated in most cancers and represents an emerging theranostic target in oncology. In glioblastoma (GBM), FAP is predominantly expressed in mesenchymal pericyte-like cells, which contribute to GBM progression by promoting angiogenesis and glioma cell prolif...
ORGANISM(S): Homo Sapiens 
2024-05-07 | PXD045057 | panorama
TranscriptomicsSTAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence
Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure cases and is characterised by reduced pericyte coverage. While the contributions of other cardiac cell types to HFpEF are well-studied, the role of pericytes remains less understood. Using murine single-nucleus...
ORGANISM(S): Homo sapiens 
2025-04-25 | E-MTAB-15019 | biostudies-arrayexpress
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 37,982 cells from diabetic...
2026-03-30 | MTBLS14184 | MetaboLights
TranscriptomicsLinking Notch signaling to ischemic stroke
Using a hitherto uncharacterized knockout mouse model of Notch 3, a Notch signaling receptor paralogue highly expressed in vascular SMCs, we uncover a striking susceptibility to ischemic stroke upon challenge. Cellular and molecular analyses of vascular SMCs derived from these animals associate Notc...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-58368 | biostudies-arrayexpress
TranscriptomicsDose-dependent dual roles of PDGF-BB–PDGFR-? in vascular remodeling and opposing effects of anti-PDGF drug-induced metastasis
Anti-PDGF agents are routinely used as a key component in front-line therapy for the treatment of various cancers. However, molecular mechanisms underlying their impact on vascular remodeling in relation to the dose issue remain poorly understood. Here we show that in high PDGF-BB-producing tumors, ...
ORGANISM(S): Mus musculus 
2013-07-22 | E-GEOD-46564 | biostudies-arrayexpress
GenomicsPI3Kβ-Regulated Pericyte Maturation Governs Vascular Remodeling
PI3Kβ-Regulated Pericyte Maturation Governs Vascular Remodeling
PRJNA543932 | ENA
TranscriptomicsExamining efficiency of enrichment of kidney pericyte-specific messages by TRAP (Translating Ribosome Affinity Purification)
The long term goal is to define the transcriptional changes that accompany pericyte-to-myofibroblast transition in fibrotic kidney disease. Medullary pericytes are identified by their expression of a eGFPL10a fusion protein whose expression is driven by a Col1a1 promoter. Pericyte-specific RNA is g...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-50439 | biostudies-arrayexpress
Sort   by:  
 Page size