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TranscriptomicsMicroarray Analysis Gene Expression Profiles in Laryngeal Muscle After Recurrent Laryngeal Nerve Injury
The pathophysiology of recurrent laryngeal nerve (RLN) transection injury is rare in that it is characteristically followed by a high degree of spontaneous reinnervation, with reinnervation of the laryngeal adductor complex (AC) preceding that of the abducting posterior cricoarytenoid (PCA) muscle. ...
ORGANISM(S): Rattus norvegicus 
2016-07-01 | E-GEOD-72361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat Postnatal developmental changes in Sprague-Dawley animals in the model of neuropathic pain - spare nerve injury
Neuropathic pain is an apparently spontaneous experience triggered by abnormal physiology of the peripheral or central nervous system, which evolves with time. Neuropathic pain arising from peripheral nerve injury is characterized by a combination of spontaneous pain, hyperalgesia and allodynia. The...
ORGANISM(S): Rattus norvegicus 
2010-01-30 | E-GEOD-15041 | biostudies-arrayexpress
TranscriptomicsGene expression signatures following nerve injury in a rat model (0h-9h)
We used microarrays to distinguish the gene expression differences among different time points after injury. We generated proximal sciatic nerve (SN) tissues (0.5cm) at 0h, 0.5h, 1h, 3h, 6h and 9h after sciatic nerve resection.
ORGANISM(S): Rattus norvegicus 
2012-12-20 | E-GEOD-33175 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse sciatic peripheral nerve of uninjured mouse against implantation of a silicon device or peripheral nerve injury.
Foreign body reaction is one of the most important limiting factors to the clinical translation of implantable bioelectronics. The experiment compares the process of foreign body reaction, following the implantation of a silicon device in a mouse peripheral nerve, to that of peripheral nerve injury,...
ORGANISM(S): Mus musculus 
2022-04-30 | E-MTAB-10294 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of DRG and dorsal cord after nerve injury
Genes are up and down regualted in DRG and spinal dorsal cord after peripheral nerve injury WT male adult with sciatic and femoral nerve transection 7 days, RNA was purified from ipilateral or contralateral L4-L6 DRGs or lumbar spinal dorsal cords
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-66619 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of rat retina after intra-orbital nerve transection, intra-orbital nerve crush or no treatment
Array experiment: Animals were divided into a control group (naive), which did not undergo any experimental manipulation (n=20) and two experimental groups, one receiving an intra-orbital nerve transection (IONT, n=60) and the other an intra-orbital nerve crush (IONC, n=60) Sterile precautions were ...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-MEXP-1387 | biostudies-arrayexpress
TranscriptomicsmicroRNAs involved in neuropathic pain following a peripheral nerve injury
Peripheral nerve injury alters the expression of hundreds of proteins in dorsal root ganglia (DRG). Targeting some of these proteins has led to successful treatments for acute pain, but not for sustained postoperative neuropathic pain. The latter may require targeting multiple proteins. Since a sin...
ORGANISM(S): Rattus norvegicus 
2014-09-29 | E-GEOD-60033 | biostudies-arrayexpress
ProteomicsRat motor and sensory nerve LC-MSMS
Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. It is important to fully understand the cellular and molecular basis underlying the specificity of peripheral nerve regeneration, which means the achieving of respective ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-12-10 | PXD022097 | Pride
Lc-msms Sensory nerve Rat Motor nerve Peripheral nerve injury 
ProteomicsQuantitative Mass Spectrometry Analysis of the Injured Proximal and Distal Human Digital Nerve Ends
Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, concentrating on differences in protein ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-19 | PXD051266 | Pride
Digital nerve injury Quantitative mass spectrometry Signal transduction Peripheral nerve injury Nerve injury pathways Extracellular matrix Proteomics 
ProteomicsDemographic variables shape longitudinal proteome signatures of peripheral nerve injury in mice
Our comprehensive proteomic analysis of mouse sciatic nerves following Spared Nerve Injury (SNI) reveals new dimensions of the molecular mechanisms underlying peripheral nerve injury, shaped by sex, developmental stage, and progression over time. Building on our previous work profiling naïve sciatic...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-05 | PXD067006 | Pride
Sex-dependent Proteomics Peripheral nerve injury Age-dependent 
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