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TranscriptomicsTranscription profiling of mouse spinal cord and dorsal root ganglion to test the fundamental quantitative differences between central and peripheral nervous system transcriptomes
We used microarrays to test the fundamental quantitative differences between central and peripheral nervous system transcriptomes. Experiment Overall Design: 3 independent SC and 3 independent DRG samples were analyzed. Each sample contained material from 4 age-matched male C57B/6 mice.
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5425 | biostudies-arrayexpress
TranscriptomicsLineage-dependent spatial and functional organisation of the mammalian enteric nervous system
Single-cell transcriptomic analysis to delineate key regulators of neurogenic commitment in the enteric nervous system. To resolve the molecular profiles of ENCCs and identify transcriptional signatures of lineage restriction and differentiation, we analyzed their transcriptomes by single-cell RNA-s...
ORGANISM(S): Mus musculus 
2020-07-27 | E-MTAB-5553 | biostudies-arrayexpress
Transcriptomicshuman peripheral nervous system SAGE
expression profiles generated from sciatic nerve as well as from Schwann cells cultured thereof Keywords: other
ORGANISM(S): Homo sapiens 
2005-04-16 | E-GEOD-2529 | biostudies-arrayexpress
MetabolomicsMetabolome profiling by untargeted metabolomics and biomarker panel selection using machine-learning for patients in different stages of peripheral neuropathy induced by oxaliplatin

Background: Oxaliplatin-induced peripheral neuropathy (OIPN) poses a significant challenge for patients with colorectal tumor, often resulting in treatment interruption or discontinuation and subsequent treatment failure. Herein, a longitudinal untargeted metabolomic study to reveal the metabolom...

2025-08-14 | MTBLS12854 | MetaboLights
TranscriptomicsTranscription profiling of Drosophila FACS sorted cells derived from imaginal discs to identify genes preferentially expressed in proneural cluster cells
Fluorescence-activated cell sorting of M4-GFP wing imaginal disc cells was used to recover a purified population of the cells that comprise the proneural clusters from which sensory organ precursors of the peripheral nervous system (PNS) arise. Whole-genome microarray analysis and in situ hybridizat...
ORGANISM(S): Drosophila melanogaster 
2007-07-07 | E-GEOD-2359 | biostudies-arrayexpress
GenomicsSox10 Binding Analysis in the Central and Peripheral Nervous System
ChIP-seq of Sox10 in spinal cord and sciatic nerve 2 independent Sox10 ChIP samples each for spinal cord (CNS) and sciatic nerve (PNS), with respective inputs
ORGANISM(S): Rattus norvegicus 
2015-04-01 | E-GEOD-64703 | biostudies-arrayexpress
ProteomicsProteome profile of peripheral myelin in healthy mice and in a neuropathy model
Using the sciatic nerve as a model, we biochemically purified peripheral nervous system (PNS) myelin and systematically assessed its proteome by dedicated, partly ion mobility-enhanced data-independent acquisition (DIA) workflows with alternating low and elevated energy (MSE) modes. Specifically, we...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-20 | PXD015960 | Pride
Transcriptome Axon degeneration Mouse Dynamic range enhancement Peripheral nervous system (pns) Charcot-marie-tooth disease Label-free quantification Myelin proteome Neuropathy Demyelination 
TranscriptomicsTranscription profiling of mouse at ages P4 and P60 in sciatic nerve of wild type and with peripheral neuropathies to study disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler).
ORGANISM(S): Mus musculus 
2007-11-03 | E-GEOD-1947 | biostudies-arrayexpress
TranscriptomicsCanine Cutaneous Peripheral Nerve Sheath Tumours versus Fibrosarcomas can be Differentiated by Neuroectodermal Marker Genes in their Transcriptome.
The diagnostic differentiation of canine fibrosarcomas and peripheral nerve sheath tumors (PNST) is mainly based on their histopathologic phenotype. Histologic differentiation of these tumors can, however, be difficult and there is a lack of immunohistochemical markers to prove their histogenic orig...
ORGANISM(S): Canis lupus familiaris 
2012-10-30 | E-GEOD-34382 | biostudies-arrayexpress
ProteomicsIntegrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phosphoproteomics, and metabolomics
Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-09 | MSV000091027 | MassIVE
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