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MetabolomicsMetabolome profiling by untargeted metabolomics and biomarker panel selection using machine-learning for patients in different stages of peripheral neuropathy induced by oxaliplatin

Background: Oxaliplatin-induced peripheral neuropathy (OIPN) poses a significant challenge for patients with colorectal tumor, often resulting in treatment interruption or discontinuation and subsequent treatment failure. Herein, a longitudinal untargeted metabolomic study to reveal the metabolom...

2025-08-14 | MTBLS12854 | MetaboLights
TranscriptomicsTranscription profiling of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
A study of diabetic neuropathy in dorsal root ganglia from streptozotocin-diabetic male wistar rats over the first 8 weeks of diabetes
ORGANISM(S): Rattus norvegicus 
2006-12-10 | E-MEXP-515 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse at ages P4 and P60 in sciatic nerve of wild type and with peripheral neuropathies to study disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler).
ORGANISM(S): Mus musculus 
2007-11-03 | E-GEOD-1947 | biostudies-arrayexpress
TranscriptomicsExpression data from a Charcot-Marie-Tooth 1B neuropathy mouse model
We have generated mouse models of real CMT1B mutations in the gene encoding for myelin protein zero (P0). One of these mutants, P0S63del is retained in the ER where it elicits an unfolded protein response (UPR). Genetic ablation of the UPR factor CHOP restores the motor capacity in S63del mice. We u...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-40610 | biostudies-arrayexpress
GenomicsFecal microbiota transplantation alleviates diabetes peripheral neuropathy
Fecal microbiota transplantation alleviates diabetes peripheral neuropathy
PRJEB37479 | ENA
ProteomicsPlasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients
• Project description: Why only half of the idiopathic peripheral polyneuropathy (IPN) patients develop neuropathic pain is unknown. By conducting a proteomics analysis on IPN patients, we aimed to discover proteins and new pathways that are associated with neuropathic pain. We conducted unbiased ma...
ORGANISM(S): Homo sapiens (Human) 
2025-02-19 | PXD046464 | Pride
Lc-msms Proteomics Neuropathic pain Idiopathic peripheral neuropathy 
GenomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq2]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51031 | biostudies-arrayexpress
UnknownSerum CXCL13 reflects local B-cell mediated inflammatory demyelinating peripheral neuropathy.
Not available
S-EPMC6848485 | biostudies-literature
ClinicalPreventive Treatment of OxaLiplatin Induced peripherAl neuRopathy in Adjuvant Colorectal Cancer
This study is to evaluate PledOx for prevention of chronic chemotherapy induced peripheral neuropathy induced by oxaliplatin in patients with Stage III or high-risk Stage II colorectal cancer (CRC).
2312035 | ecrin-mdr-crc
ClinicalYiqi Wenjing Prescriptions Preventive Efficacy of Oxaliplatin-induced Peripheral Neuropathy Clinical Trial
This study is a randomized, placebo-controlled, double-blind, multicenter phase III clinical trial of Yiqi Wenjing prescriptions for Preventing Oxaliplatin-induced Peripheral Neuropathy.
2362427 | ecrin-mdr-crc
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