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TranscriptomicsGenotyping of human glioma - assessing the significance of chromosomal aberrations in cancer
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics and targeted therapeutics. Systematic efforts to analyze cancer genomes are underway, but the analysis is hampered by the lack of a statistical framework to distinguish mean...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9635 | biostudies-arrayexpress
GenomicsFrequent mutations in chromatin-remodelling genes in pulmonary carcinoids
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n¼54), genome/exome (n¼44) and transcriptome (n¼69) sequencing of pulmonary...
EGAS00001000650 | EGA
Genomicsena-DATASET-RTL-10-04-2014-14:57:02:227-16 - samples
Fernandez-Cuesta et al, 2014, Nature Communication, Whole exome sequencing data set
EGAD00001000820 | EGA
Genomicsena-DATASET-RTL-03-04-2014-12:58:19:275-109 - samples
Fernandez-Cuesta et al., 2014, Nature Communication, Whole genome sequencing was performed using a read length of 2x100 bp for all samples. On average, 110 Gb of sequence were produced per sample, aiming a mean coverage of 30x for both tumour and matched normal.
EGAD00001000813 | EGA
GenomicsCA_SNP_6.0 - samples
SNP 6.0 arrays of carcinoid samples
EGAD00010000546 | EGA
Genomicsena-DATASET-RTL-26-03-2014-08:44:34:042-926 - samples
Fernandez-Cuesta et al, 2014, Nature Communication, RNA Sequencing data set
EGAD00001000795 | EGA
Genomicsena-DATASET-UCL-ICH-25-11-2015-12:32:35:398-26 - samples
Description not provided
EGAD00001001687 | EGA
GenomicsTelomerase activation by genomic rearrangements in high-risk neuroblastoma
Neuroblastoma is a malignant pediatric tumor of the sympathetic nervous system1. Roughly half of these tumors regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavorable clinical course despite intensive multimodal treatment, and their molecular b...
EGAS00001001308 | EGA
GenomicsDAC University Hospital Cologne
Data Access Committee EGAC00001000361
EGAC00001000361 | EGA
GenomicsIntegrative analysis of small cell lung cancer
Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype. We conducted integrated analysis of genome sequencing, transcriptome, and copy number analysis and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million basepairs. Evidence for inactivation of TP53 and...
EGAS00001000299 | EGA
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