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ProteomicsA Mitochondria-Driven Quality Control Pathway Eliminates Mislocalized Peroxisomal Membrane Proteins
Protein quality control (PQC) systems are essential for maintaining a healthy proteome by removing aberrant proteins, including mislocalized proteins. However, the mechanisms for eliminating mislocalized Peroxisomal Membrane Proteins (PMPs) have remained elusive. Here, using quantitative proteomics ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD069489 | Pride
Peroxisome Protein degradation March5 E3 ligases Mul1 Ubiquitin Protein quality control Peroxisomal membrane proteins (pmps) 
GenomicsA Mitochondria-Driven Quality Control Mechanism for Peroxisomal Membrane Proteins
A Mitochondria-Driven Quality Control Mechanism for Peroxisomal Membrane Proteins
PRJNA1366466 | ENA
TranscriptomicsA Mitochondria-Driven Quality Control Mechanism for Peroxisomal Membrane Proteins
Peroxisomes are essential organelles involved in lipid and reactive oxygen species metabolism, and their function requires proper targeting of peroxisomal membrane proteins (PMPs). When peroxisome biogenesis fails, as occurs in peroxisome biogenesis disorders, PMP levels decrease markedly, yet the u...
ORGANISM(S): Homo sapiens 
2026-05-13 | GSE310531 | GEO
UnknownCell-free sorting of peroxisomal membrane proteins from the endoplasmic reticulum.
Not available
S-EPMC3107335 | biostudies-literature
UnknownPeroxisomal membrane proteins insert into the endoplasmic reticulum.
Not available
S-EPMC2883949 | biostudies-literature
UnknownSaccharomyces cerevisiae cells lacking Pex3 contain membrane vesicles that harbor a subset of peroxisomal membrane proteins.
Not available
S-EPMC7611440 | biostudies-literature
UnknownA dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins.
Not available
S-EPMC10995880 | biostudies-literature
UnknownA New Yeast Peroxin, Pex36, a Functional Homolog of Mammalian PEX16, Functions in the ER-to-Peroxisome Traffic of Peroxisomal Membrane Proteins.
Not available
S-EPMC5693695 | biostudies-literature
UnknownAllosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
Not available
S-EPMC5353646 | biostudies-literature
TranscriptomicsPeroxisome function relies on organelle-associated mRNA translation
Crucial metabolic functions of peroxisomes rely on a variety of peroxisomal membrane proteins (PMPs). While mRNA transcripts of PMPs were shown to be colocalized with peroxisomes, the process by which PMPs efficiently couple translation with targeting to the peroxisomal membrane remained elusive. He...
ORGANISM(S): Saccharomyces cerevisiae 
2022-01-12 | GSE113567 | GEO
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