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ProteomicsThe stress-sensing MARCH5 axis governs blood cancer apoptotic resilience via tractable protein–protein interactions
The mitochondrial E3 ligase MARCH5 has consistently emerged as a dependency in unbiased screens in acute myeloid leukemia and myeloma, yet the underpinning mechanism remains ill-defined. Here, we show that MARCH5 cooperates with UBE2J2 and MFN2, forming a stress-sensing complex at mitochondria–ER co...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD082032 | Pride
Hematological malignancies Resistance Bcl2 Ube2j2 Mfn2 Apoptosis March5 
ProteomicsMARCH5 interactome detection using PUP-IT
MARCH5 (also referred to as MITOL) is known as a mitochondrial ubiquitin ligase. It regulates the mitochondria homeostasis by ubiquitinating several important mitochondrial fusion/fission regulators. In this study, we used a proximity labeling method PUP-IT to systematically identify potential MARC...
ORGANISM(S): Homo Sapiens 
PXD029348 |
ProteomicsMarch5-mediated Trim28 degradation preserves islet β-cell function in mice
Insulin deficiency from β-cell dysfunction underpins both type 1 and type 2 diabetes. However, the regulatory pathways underlying β-cell function remain incompletely understood. Here, we identify that March5 and Trim28 as key modulators of β-cell function. March5 is downregulated and Trim28 upregula...
ORGANISM(S): Homo sapiens (Human) 
2025-07-24 | PXD066332 | Pride
Islet transplantation Mafa Kindlin-2 Insulin secretion Glucose intolerance 
UnknownUbiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy.
Not available
S-EPMC8579195 | biostudies-literature
UnknownMARCH5 promotes hepatocellular carcinoma progression by inducing p53 ubiquitination degradation.
Not available
S-EPMC11166841 | biostudies-literature
UnknownMARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms.
Not available
S-EPMC9984497 | biostudies-literature
UnknownOuter mitochondrial membrane E3 Ub ligase MARCH5 controls de novo peroxisome biogenesis.
Not available
S-EPMC11706706 | biostudies-literature
UnknownMarch5-mediated Trim28 degradation preserves islet β-cell function in mice.
Not available
S-EPMC12317142 | biostudies-literature
UnknownMARCH5 promotes aerobic glycolysis to facilitate ovarian cancer progression via ubiquitinating MPC1.
Not available
S-EPMC11263418 | biostudies-literature
UnknownMARCH5 Promotes Cardiac Hypertrophy by Regulating Akt/mTOR/Gsk-3β/GATA4 Signalling Pathway.
Not available
S-EPMC12318481 | biostudies-literature
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