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TranscriptomicsParkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation
Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-68921 | biostudies-arrayexpress
TranscriptomicsMitofusin 2 expression in muscle decreases during aging and generates a gene signature characteristic of aged muscle
Mitochondrial fusion and fission proteins regulate mitochondrial quality control and mitochondrial metabolism. In turn, mitochondrial dysfunction is associated with aging, although its causes are still under debate. Here, we show that aging is characterized by a progressive reduction of Mitofusin 2 ...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-71501 | biostudies-arrayexpress
ProteomicsLC-MS/MS of human MFN2 interaction proteins
LC-MS/MS of human MFN2 interaction proteins from 293T cells or 786-O cells
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033112 | Pride
Mfn2 Human Lc-ms/ms 
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsRNA sequencing of MShef11 WT, MFN2R94Q/+, MFN2 R94Q/R94Q differentiated to limb innervating motor neurons
We have generated CRISPR edited versions of hESC line MShef11 to produce MFN2 R94Q/+ and MFN2 R94Q/R94Q lines as a model for Charcot Marie Tooth Disease (CMT) 2A. This were differentiated to limb innervating motor neurons, the predominantly affected cell time in CMT2A and RNA was examined to investi...
ORGANISM(S): Homo sapiens 
2022-07-28 | E-MTAB-10831 | biostudies-arrayexpress
ProteomicsIdentification of Mfn2 interacting proteins in homeostatic endothelial cells
Identification of Mfn2 interacting proteins in homeostatic endothelial cells using affinity purification-mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2021-03-11 | PXD024620 | Pride
Lc-ms Ap-ms 
GenomicsAnalysis of Wild Type and MFN2-/- Macrophage Transcriptomes
Analysis of Wild Type and MFN2-/- Macrophage Transcriptomes
PRJNA715471 | ENA
GenomicsRNA-seq analysis with MFN2-deficient human iPS cells
RNA-seq analysis with MFN2-deficient human iPS cells
PRJNA939711 | ENA
GenomicsNFAT1 (NFATc2) ChIP-seq in wild-type and Mfn2-/- regenerating myofibers
NFAT1 (NFATc2) ChIP-seq in wild-type and Mfn2-/- regenerating myofibers
PRJNA767659 | ENA
ProteomicsPGC1-α drives Mfn2-linked Mitochondrial Fusion aiding Glioblastoma Cell Survival under TMZ stress
Glioblastoma Multiforme (GBM) is an extremely aggressive primary brain-tumor with a median-survival rate of < 2 years. Higher risk in surgery has shifted the treatment paradigm towards combined chemotherapies. Interestingly, arduous dependency on chemotherapy has shown recurrence. Recent studies hav...
ORGANISM(S): Homo sapiens (Human) 
2025-10-10 | PXD063885 | Pride
Mitochondrial fusion Glioblastoma Mfn2 Temozolomide Pgc1α 
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