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ProteomicsIdentification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse
Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016060 | Pride
Patient derived xenograft Tumor antigen Peptidome Hla 
TranscriptomicsMicroarray expression analysis of bevacizumab-resistant glioblastomas compared to pre-treatment paired specimens
Paired samples of resected tumor from glioblastoma patients: Pre and post Avastin-treatment samples for each patient in the cohort.
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1380 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pilocytic astrocytoma to develop molecular signatures
Pilocytic astrocytomas (PAs) are the most common glioma in children. While many PAs; are slow growing or clinically indolent, others exhibit more aggressive features with tumor; recurrence and death. In order to identify genetic signatures that might predict PA clinical; behavior, we performed gene ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neocortical and cerebellar astrocytes
Affymetrix Mouse Genome 430 2.0 GeneChip microarrays were used to analyze murine neocortical and cerbellar astrocytes generated from postnatal (PN) day 1 wild-type (ICR) pups. Experiment Overall Design: Three samples each of murine neocortical and cerebellar astrocytes were analyzed.
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5582 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of medulloblastoma tumors in mice
The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally-stabilized murine N-mycT58A into neural stem cells (NSCs) from perinatal murine cerebellum, brain s...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-36594 | biostudies-arrayexpress
Genomics2013-11-19-17-24-36-breez-MB-2013-10-18-Whole_exome_DNAseq_Medulloblastoma - samples
Illumina HiSeq sequence data (with >80x coverage) were aligned to the hg19 human reference genome assembly using BWA (Li and Durbin, 2009); duplicate reads were removed from the final BAM file. No realignment or recalibration was performed. The whole exome sequencing data of 20 SHH medulloblastomas ...
EGAD00001000698 | EGA
GenomicsSHH medulloblastoma samples
Sequencing data of human SHH medulloblastoma samples
EGAS00001000607 | EGA
ProteomicsVestibular schwannoma is comprised of neural crest and immune subgroups
Vestibular schwannomas (VS) are tumors arising from cranial nerve Schwann cells that cause significant morbidity and are treated with surgery and irradiation. We describe a DNA methylation-based classification of VS into neural crest and immune enriched subgroups and validate our findings using bulk...
ORGANISM(S): Homo Sapiens 
PXD014883 | panorama
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