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ProteomicsHigh-throughput identification of functional regulatory SNPs in systemic lupus erythematosus
Genome-wide association studies implicate multiple loci in risk for systemic lupus erythematosus (SLE), but few contain exonic variants, rendering systematic identification of non-coding variants essential to decoding SLE genetics. We utilized SNP-seq and bioinformatic enrichment to interrogate 2180...
ORGANISM(S): Homo sapiens (Human) 
2024-08-02 | PXD048367 | Pride
Lc-msms Human B cell Sle 
TranscriptomicsExpression profiling analysis of brain from ADAR2 mutant mice
ADARs, short for adenosine deaminases acting on RNA, were first found by their characteristic activity of deaminating up to 50% of all adenosines in double-stranded RNA in vitro. C. elegans has two ADARs, only one is found in the fly, and mammals express three ADARs. Importantly, the spectrum of phy...
ORGANISM(S): Mus musculus 
2010-11-01 | E-GEOD-15383 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression in jnk1-/-jnk2-/- immortalized mouse embryonic fibroblasts compared to wildtype counterparts co-cultivated with differentiating keratinocytes
Analysis of JNK-dependent fibroblast-derived soluble factors at gene expression level. The hypothesis tested in the present study was that loss of c-Jun N-terminal kinases 1 and 2, JNK1 and JNK2, in MEFs causes a strong alteration of the gene expression program coding for soluble factors, which prom...
ORGANISM(S): Mus musculus 
2013-11-26 | E-GEOD-48612 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of keratinocyte gene expression during their course of differentiation in presence or absence of JNK1,2-deficient or wildtype immortalized mouse embryonic fibroblasts (MEFs)
Analysis of keratinocyte differentiation in presence or absence of fibroblast-derived JNK-dependent soluble factors in vitro. The hypothesis tested in the present study was that JNK-dependent fibroblast-derived soluble factors promote an efficient keratinocyte differentiation. Results provide import...
ORGANISM(S): Homo sapiens 
2013-11-26 | E-GEOD-48613 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of leaves of Arabidopsis thaliana Col-0 plants exposed to volatile pinenes (treatment) or hexane (control)
Volatile organic compounds (VOCs) may play a role in systemic acquired resistance (SAR), a salicylic acid (SA)-associated, broad-spectrum immune response in systemic, healthy tissues of locally infected plants. Four-to-five-week-old plants were exposed for three days to a mixture of volatile pinenes...
ORGANISM(S): Arabidopsis thaliana 
2017-06-01 | E-MTAB-5475 | biostudies-arrayexpress
UnknownInternational multicenter study comparing COVID-19 in patients with cancer to patients without cancer: Impact of risk factors and treatment modalities on survivorship.
Not available
S-EPMC9981148 | biostudies-literature
UnknownGut microbiota density influences host physiology and is shaped by host and microbial factors.
Not available
S-EPMC6342524 | biostudies-literature
GenomicsData access policy for PDTX Breast Cancer data from Bruna et al (2016), Cell.
Data Access Committee EGAC00001000540
EGAC00001000540 | EGA
GenomicsInternational Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN)

The genetic makeup of an individual strongly influences the risk of developing systemic lupus erythematosus (SLE). The identification of genes that predispose an individual to SLE will lead to earlier and better diagnosis, better treatments, and possibly prevention.

To this end, t...

phs000216.v1.p1 | EGA
UnknownSimvastatin in Critically Ill Patients with Covid-19.
Not available
S-EPMC10755839 | biostudies-literature
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