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MetabolomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 1)
Not available
ORGANISM(S): Plasmodium falciparum 
ST002106 | MetabolomicsWorkbench
MetabolomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 3)
Not available
ORGANISM(S): Plasmodium falciparum 
ST002108 | MetabolomicsWorkbench
MetabolomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway (Part 2)
Not available
ORGANISM(S): Plasmodium falciparum 
ST002107 | MetabolomicsWorkbench
ProteomicsGenetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway
Plasmodium falciparum, the causative agent of malaria, continues to remain a global health threat since these parasites are now resistant to all anti-malaria drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required to combat malaria. P. falciparum paras...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 365.1 
2022-09-12 | PXD032358 | Pride
Plasmodium falciparum Pfa-m17 Malaria Haemoglobin digestion 
UnknownSelective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.
Not available
S-EPMC5609037 | biostudies-literature
UnknownNatural triterpenic phenolic esters target PfA-M17 in Plasmodium falciparum.
Not available
S-EPMC12866511 | biostudies-literature
ProteomicsOn-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
To combat the global burden of malaria, development of new drugs to replace or complement current therapies are urgently required. As drug resistance to existing treatments and clinical failures continue to rise, compounds targeting multiple life cycle stages and species need to be developed as a hi...
ORGANISM(S): Homo sapiens (Human) 
2024-05-06 | PXD046006 | Pride
Malaria Antimalarial Plasmodium falciparum 
UnknownStructure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
Not available
S-EPMC2809755 | biostudies-literature
UnknownActive site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
Not available
S-EPMC7948507 | biostudies-literature
UnknownA metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
Not available
S-EPMC9270245 | biostudies-literature
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