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GenomicsConserved epigenomic signatures between mouse and human elucidate immune basis of Alzheimer's disease
Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cognitive decline. Several genes have been implicated in AD, but chromatin state alterations during ne...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-65159 | biostudies-arrayexpress
TranscriptomicsThe genome of the zebra finch, a songbird
This study was part of a larger study on the zebra finch genome (Warren et al 2010. Nature). Here we present a summary of the specific experiment on singing-regulated gene expression. To evaluate the genomic landscape of learned vocal communication, we profiled gene expression in the zebra finch son...
ORGANISM(S): Taeniopygia guttata 
2010-05-15 | E-GEOD-19900 | biostudies-arrayexpress
GenomicsVocal learning-associated convergent evolution in mammalian regulatory elements and proteins
Vocal learning-associated convergent evolution in mammalian regulatory elements and proteins
PRJNA777475 | ENA
GenomicsCell type-specific oxidative stress genomic signatures in the globus pallidus of dopamine depleted mice
Cell type-specific oxidative stress genomic signatures in the globus pallidus of dopamine depleted mice
PRJNA661054 | ENA
GenomicsMachine learning sequence prioritization for cell type-specific enhancer design
Machine learning sequence prioritization for cell type-specific enhancer design
PRJNA720048 | ENA
TranscriptomicsThe singing genome: Core and region enriched gene expression define behaviorally regulated gene networks
Studies of transcriptional networks in multi-cellular organisms usually focus on isolated cells and typically assume that the discovered gene networks represent those present in connected cells within a complex organ like the brain. However, similar cell types connected in diverse anatomical network...
ORGANISM(S): Taeniopygia guttata 
2012-12-13 | E-GEOD-33365 | biostudies-arrayexpress
TranscriptomicsMouse hypothalamus and whole brain: control vs. sodium craving
Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked ACTH and by reproduction. Genome-wide microarrays in sodium deficient mice, or following ACTH infusion, showed upregulation of hypothalamic genes, including DARPP-32, dopamine rec...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-29451 | biostudies-arrayexpress
TranscriptomicsAvian 12th motor neuron
To determine what kind of genes are involved in vocal learning ability, we performed microarray experiments using 3 vocal learning species (zebra finch, budgerigar, Anna's hummingbird) and 2 non-vocal learning species(ring dive, and Japanese quail) from the bird group. All of the animals are male ad...
ORGANISM(S): Melopsittacus undulatus 
2012-05-30 | E-GEOD-33667 | biostudies-arrayexpress
GenomicsCore and region enriched networks of behaviorally regulated genes: the singing epigenome
We queried a songbird brain to discover behaviorally regulated transcriptional mechanisms relevant for speech behavior. About 10% of zebra finch genes showed regulation during singing, and most were brain-region specific. We propose that the brain-regional diversity of the singing-regulated gene net...
ORGANISM(S): Taeniopygia guttata 
2014-12-08 | E-GEOD-63936 | biostudies-arrayexpress
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