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ProteomicsBoth L-lactyl and D-lactyl enantiomers modify histones in mouse testis
Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues. This modification exists as two enantiomers, L- a...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-01 | PXD070921 | Pride
Lysine lactylation Histones Targeted proteomics 
ProteomicsBoth L-lactyl and D-lactyl enantiomers modify histones in mouse testis
Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues. This modification exists as two enantiomers, L- a...
ORGANISM(S): Mus Musculus 
PXD070274 | panorama
ProteomicsMind Your Spectra: Points to be Aware of when Validating the Identification of Isobaric Histone Peptidoforms
Mass spectrometry (MS) is now well recognized as a powerful technique to identify and quantify post-translational modifications (PTMs), overcoming many of the limitations of antibody-based methods. Histones, which play a central role in all DNA-templated processes, are regulated by a wealth of dynam...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD057347 | Pride
Histone h3 variants Acylations Overpropionylation Isobaric peptides 
ProteomicsShared and specific targets of Arabidopsis immune MAPKs
In Arabidopsis, mitogen-activated protein kinases MPK3, MPK4 and MPK6 constitute essential relays for a variety of functions including cell division, development and innate immunity. While some substrates of MPK3, MPK4 and MPK6 have been identified, the picture is still far from complete. To identif...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-12-06 | PXD006807 | Pride
Arabidopsis thaliana Mapkinases Immunity Phosphoproteomics Signaling 
ProteomicsMS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones
Histones and histone variants are essential components of the nuclear chromatin. While mass spectrometry has opened a large window to their characterization and functional studies, their identification from proteomic data remains challenging. Indeed, the current interpretation of mass spectrometry d...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-11 | PXD005489 | Pride
Proteomics Mass spectrometry Histone Chromatin Histone variants 
ProteomicsSystematic genetic and proteomic screens identify yeast H2BK37 and mammalian H2BK34 methylation as an evolutionary conserved meiotic mark
Gametes are highly differentiated cells specialized to carry and protect the parental genetic information. Their chromatin organization is highly compacted and the establishment of this nuclear structure involves many chromatin processes. Technical difficulties exclude the analysis of precise histon...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-09-21 | PXD006213 | Pride
Methylation Sporulation Histone Spermatogenesis Meiosis 
ProteomicsMulti-omic analysis of gametogenesis reveals a novel signature at the promoters and distal enhancers of active genes
Epigenetic regulation of gene expression is tightly controlled by the dynamic modification of histones by chemical groups, the diversity of which has largely expanded over the past decade with the discovery of lysine acylations, catalyzed from acyl-coenzymes A. Here, we investigated the dynamics of ...
ORGANISM(S): Mus musculus (Mouse) Saccharomyces cerevisiae (Baker's yeast) 
2020-03-26 | PXD015380 | Pride
Promoters and enhancers Omics data integration Crotonylation Mouse spermatogenesis Histones 
ProteomicsChromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity
Mitogen-activated protein kinases constitute essential signaling mechanisms linking external signal perception to gene expression in all eukaryotes. In Arabidopsis, MAPKs are found in the cytoplasmic and nuclear compartments, but no nuclear phosphoproteomic studies of mapk mutants were performed so ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-01-07 | PXD009823 | Pride
Arabidopsis thaliana Immune mapks Phosphoproteomics 
TranscriptomicsMulti-omic analysis of gametogenesis reveals a novel signature at the promoters and distal enhancers of active genes
Epigenetic regulation of gene expression is tightly controlled by the dynamic modification of histones by chemical groups, the diversity of which has largely expanded over the past decade with the discovery of lysine acylations, catalyzed from acyl-coenzymes A. Here, we investigated the dynamics of ...
ORGANISM(S): Mus musculus 
2020-03-11 | E-MTAB-8328 | biostudies-arrayexpress
ProteomicsDOT1L regulates chromatin reorganization and gene expression during sperm differentiation
Spermatozoa have a unique genome organization: their chromatin is almost completely devoid of histones and is formed instead of protamines which confer a high level of compaction and preserve paternal genome integrity until fertilization. Histone-to-protamine transition takes place in spermatids and...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-30 | PXD030734 | Pride
Dotl Mouse spermatogenesis 
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