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TranscriptomicsGene Profiling in the Livers of Wild-Type and PPARalpha-Null Mice Exposed to Perfluorooctanoic Acid (PFOA)
Unlike the PPARalpha agonist W14,643, PFOA is capable of inducing effects independently of PPARa. Genes altered in the PPARalpha-null mouse following exposure to PFOA included those associated with fatty acid metabolism, inflammation, xenobiotic metabolism, and cell cycle progression. The specific s...
ORGANISM(S): Mus musculus 
2008-05-22 | E-GEOD-9796 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung and liver from low and high dose Perfluorooctanoic Acid exposed fetuses
Exposure to PFOA during gestation altered the expression of genes related to fatty acid catabolism in both the fetal liver and lung. In the fetal liver, the effects of PFOA were robust and also included genes associated with lipid transport, ketogenesis, glucose metabolism, lipoprotein metabolism, ...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-13044 | biostudies-arrayexpress
TranscriptomicsTranscriptomic responses of zebrafish embryos to sublethal exposure to perfluorooctanoic acid (PFOA): A 96-Hour RNA-seq Study
Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic chemicals widely detected in the environment and associated with adverse effects such as developmental toxicity, endocrine disruption, and hepatotoxicity. Traditional chemical risk assessment relies on chronic animal studies, which ...
ORGANISM(S): Danio rerio 
2026-05-01 | E-MTAB-15671 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and PPARalpha-null mutants response to PFOA
Toxicogenomic Dissection of the Perfluorooctanoic Acid (PFOA) Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARalpha and CAR; We performed a toxicogenomics dissection of the transcript profiles in the mouse liver after exposure to PFOA. We uncovered classes o...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9786 | biostudies-arrayexpress
GenomicsAD PFOA
AD PFOA Raw sequence reads
PRJNA1171116 | ENA
ModelsLoccisano2011-pharmacokinetics of PFOA and PFOS in the monkey
Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under intense scrutiny. Limited pharmacokinetic data is available in humans; however, human data exists f...
2020-03-20 | MODEL2003190002 | BioModels
ProteomicsThe Roles of PFOA and PFOS on Human Sperm Capacitation
PFOS and PFOA are persistent organic pollutants known to impair human reproduction, but their effects and molecular mechanisms on human sperm remain unclear. Here, we conducted comprehensive proteomic and phosphoproteomic profiling of human sperm exposed to PFOS and PFOA during capacitation to provi...
ORGANISM(S): Homo Sapiens 
2025-09-28 | PXD068914 |
TranscriptomicsMechanism for hepatic tumor promotion by PFOA in rainbow trout
Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents. Humans are not susceptible to peroxisome proliferation and are thought to be refractory to carcinogenesis by PFOA and other PPs. However, previous studies with rainbow trout have shown that they...
ORGANISM(S): Oncorhynchus mykiss 
2007-08-31 | E-GEOD-7837 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fetus exposed to lung and liver of Perfluorooctane sulfonate (PFOS)
Most of the transcriptional changes induced by PFOS in the fetal mouse liver and lung were related to activation of PPARalpha. When compared to the transcript profiles induced by PFOA (Pubmed ID 17681415), few remarkable differences were found other than up-regulation of Cyp3a genes. Because PFOS ...
ORGANISM(S): Mus musculus 
2009-05-16 | E-GEOD-13302 | biostudies-arrayexpress
TranscriptomicsMechanistic information on perfluorooctanoic acid (PFOA) exposure in zebrafish (Danio rerio)
Perfluorooctanoic acid (PFOA) is one of the most used perfluorinated compounds in numerous applications and can be detected in environmental samples from around the globe. The aquatic environment is an important site for PFOA deposit. Nevertheless, the exact mode of action and its resulting toxicolo...
ORGANISM(S): Danio rerio 
2013-07-20 | E-GEOD-19908 | biostudies-arrayexpress
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