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TranscriptomicsCultured chicken embryonic hepatocytes (CEH) exposed to linear PFOS (L-PFOS) or technical-grade PFOS (T-PFOS)
Recently it was discovered that the perfluorooctane sulfonate (PFOS) detected in wildlife, such as fish-eating birds, had a greater proportion of linear PFOS (L-PFOS) than the manufactured technical product (T-PFOS), which contains linear and branched isomers. This suggests toxicological studies bas...
ORGANISM(S): Gallus gallus 
2011-10-28 | E-GEOD-33291 | biostudies-arrayexpress
MetabolomicsPerfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity
Not available
ORGANISM(S): Mus musculus 
ST001525 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse fetus exposed to lung and liver of Perfluorooctane sulfonate (PFOS)
Most of the transcriptional changes induced by PFOS in the fetal mouse liver and lung were related to activation of PPARalpha. When compared to the transcript profiles induced by PFOA (Pubmed ID 17681415), few remarkable differences were found other than up-regulation of Cyp3a genes. Because PFOS ...
ORGANISM(S): Mus musculus 
2009-05-16 | E-GEOD-13302 | biostudies-arrayexpress
TranscriptomicsLiver Cyprinus carpio PFOS experiment
Perfluorooctane sulfonate (PFOS) has been manufactured for over 50 years in increasing quantities and has been used for several industrial and commercial aims. Due to the persistence and the bioaccumulation of this pollutant, it can be found worldwide in wildlife and humans. Biochemical effects of P...
ORGANISM(S): Cyprinus carpio 
2008-08-15 | E-GEOD-10980 | biostudies-arrayexpress
ProteomicsProteomics reveals PFOS-induced alteration of lipid utilization and xenobiotic metabolism in a model of PFOS-augmented diet-induced fatty liver
Perfluorooctanesulfonic acid (PFOS) is a persistent, bio-accumulative pollutant that has been used for the last 60+ years in numerous industrial and commercial applications. In mice, PFOS administration is known to induce hepatomegaly and hepatic steatosis. The aim of the present study was to evalua...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-30 | PXD016161 | Pride
Perfluorinated compounds Pfos Proteomics Liver High fat diet Weight loss Nafld 
ModelsLoccisano2011-pharmacokinetics of PFOA and PFOS in the monkey
Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under intense scrutiny. Limited pharmacokinetic data is available in humans; however, human data exists f...
2020-03-20 | MODEL2003190002 | BioModels
ProteomicsThe Roles of PFOA and PFOS on Human Sperm Capacitation
PFOS and PFOA are persistent organic pollutants known to impair human reproduction, but their effects and molecular mechanisms on human sperm remain unclear. Here, we conducted comprehensive proteomic and phosphoproteomic profiling of human sperm exposed to PFOS and PFOA during capacitation to provi...
ORGANISM(S): Homo Sapiens 
PXD068914 |
ProteomicsIntergenerational and biochemical responses of the Western honey bee (Apis mellifera) to sublethal perfluorooctane sulfonate (PFOS) exposures.
Bees are threatened by multiple stressors, including environmental contaminants such as perfluorooctane sulfonate (PFOS). In this exposure effect study, small whole colonies of A. mellifera (2500 bees) were exposed to sublethal PFOS concentrations (5 to 20 µg L-1 in sugar syrup) over a 25-day period...
ORGANISM(S): Apis mellifera (Honeybee) 
2026-03-18 | PXD070054 | Pride
Ecotoxicity Proteomics Honey Effects study Bee colony Oxidative stress Pfas Cage Bee. 
TranscriptomicsExpression data from wild-type and PPARalpha-null mice exposed to perfluorooctane sulfonate (PFOS)
Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife. Although blood levels of PFOS have begun to decline, health concerns remain because of the long half-life of PFOS in humans. Like other PFAAs, suc...
ORGANISM(S): Mus musculus 
2010-10-01 | E-GEOD-22871 | biostudies-arrayexpress
TranscriptomicsHepatic miRNA profiles and thyroid hormone homeostasis in rats exposed to dietary potassium perfluorooctanesulfonate (PFOS) [miRNA]
Perfluorooctanesulfonate (PFOS) has been widely used in a variety of industrial and commercial applications as a surfactant and stain repellent. PFOS causes liver damage (including liver tumors) in experimental animals, primarily via interaction with PPARa and CAR/PXR. We investigated the involvemen...
ORGANISM(S): Rattus norvegicus 
2015-08-01 | E-GEOD-69521 | biostudies-arrayexpress
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