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GenomicsPfs48/45 nanobodies block Plasmodium falciparum transmission
Pfs48/45 nanobodies
PRJEB88774 | ENA
ProteomicsCryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Plasmodium falciparum Pfs230 and Pfs48/45 are the leading candidates for malaria transmission-blocking vaccines. However, it remains unknown how the two interact and if additional domains in Pfs230 are potential vaccine candidates. Here we report a 3.36 Å resolution cryo-electron microscopy structur...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-08-08 | PXD060667 | Pride
Transmission blocking Cryo-em Pfs48/45 Vaccine Mrna-lnp Malaria Nanobody Fertilization Plasmodium falciparum Pfs230 
ProteomicsFLAG-tag based co-immunoprecipitation of the Plasmodium falciparum Pfs230:Pfs48/45 complex
Malaria is a devastating disease, causing over half a million deaths annually mostly amongst young children. Transmission blocking vaccines aim to induce immunity against the sexual stages of the causative Plasmodium parasites, preventing human-to-mosquito transmission. Two promising transmission bl...
ORGANISM(S): Plasmodium falciparum 
2025-10-09 | PXD060716 | Pride
Malaria Pfs48/45 Plasmodium falciparum Pfs230 Lc-ms/ms 
UnknownPfs48/45 nanobodies block Plasmodium falciparum transmission.
Not available
S-EPMC12858062 | biostudies-literature
UnknownStructure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies.
Not available
S-EPMC11844449 | biostudies-literature
ProteomicsPfs230 and Pfs48/45 complex SDA XL-MS
Asexual P. falciparum parasite cultures were maintained, gametocytes harvested and pellets lysed prior to chromatography procedures including size exclusion. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by SDS-PAGE, gel bands excised and subjected to tr...
ORGANISM(S): Plasmodium (plasmodium) 
2026-01-27 | PXD060341 | JPOST Repository
UnknownStructure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Not available
S-EPMC9509318 | biostudies-literature
UnknownStructure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins.
Not available
S-EPMC7381611 | biostudies-literature
UnknownStructural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45.
Not available
S-EPMC6203815 | biostudies-literature
UnknownStructural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody.
Not available
S-EPMC6148045 | biostudies-literature
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