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Proteomicsvalidation of the purified sCM12 protein from Pfs230
Aim was to verify the identity of sCM12, a domain of Pfs230. Pfs230 is a P. falciparum antigen that is a transmission blocking vaccine target. For questions about this study, please contact matthijs.jore@radboudumc.nl.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-10-30 | PXD039716 | Pride
Pfs230 plasmodium scm12 
ProteomicsCryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Plasmodium falciparum Pfs230 and Pfs48/45 are the leading candidates for malaria transmission-blocking vaccines. However, it remains unknown how the two interact and if additional domains in Pfs230 are potential vaccine candidates. Here we report a 3.36 Å resolution cryo-electron microscopy structur...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-08-08 | PXD060667 | Pride
Transmission blocking Cryo-em Pfs48/45 Vaccine Mrna-lnp Malaria Nanobody Fertilization Plasmodium falciparum Pfs230 
GenomicsNGS of Nanobodies against endogenous Plasmodium falciparum Pfs230
Next-Generation Sequencing of phage display panning outputs to find nanobodies against domains 13 and 14 of Pfs230
PRJEB85614 | ENA
ProteomicsFLAG-tag based co-immunoprecipitation of the Plasmodium falciparum Pfs230:Pfs48/45 complex
Malaria is a devastating disease, causing over half a million deaths annually mostly amongst young children. Transmission blocking vaccines aim to induce immunity against the sexual stages of the causative Plasmodium parasites, preventing human-to-mosquito transmission. Two promising transmission bl...
ORGANISM(S): Plasmodium falciparum 
2025-10-09 | PXD060716 | Pride
Malaria Pfs48/45 Plasmodium falciparum Pfs230 Lc-ms/ms 
UnknownStructure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins.
Not available
S-EPMC7381611 | biostudies-literature
UnknownNanobodies against Pfs230 block Plasmodium falciparum transmission.
Not available
S-EPMC9788556 | biostudies-literature
UnknownIdentification of domains within Pfs230 that elicit transmission blocking antibody responses.
Not available
S-EPMC6708081 | biostudies-literature
UnknownStructure of endogenous Pfs230:Pfs48/45 in complex with potent malaria transmission-blocking antibodies.
Not available
S-EPMC11844449 | biostudies-literature
UnknownOuter membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230.
Not available
S-EPMC6614402 | biostudies-literature
UnknownPfs230 domain 12 is a potent malaria transmission-blocking vaccine candidate.
Not available
S-EPMC12594191 | biostudies-literature
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