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TranscriptomicsProstaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4
Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to d...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9847 | biostudies-arrayexpress
ProteomicsMouse PPAR gamma with/without 15-keto-PGE2
15-keto-PGE2 is proposed as an endogenous ligand of PPAR gamma. The modification of 15-keto-PGE2 can induce PPAR gamma transcriptional activation. This project aims to identify the binding site of 15-keto-PGE2 on PPAR gamma.
ORGANISM(S): Mus musculus (Mouse) 
2025-02-17 | PXD059654 | Pride
15-keto-pge2 Ppar gamma 
TranscriptomicsTranscription profiling by array of human dendritic cells after Poly(I:C)-based or PGE2-based maturation
Generation of human monocyte-derived DCs Peripheral blood mononuclear cells (PBMC) were isolated by Ficoll density centrifugation from buffy coats or whole blood of healthy donors and resuspended in serum-free medium (CellGro, CellGenix GmbH, Freiburg, Germany), supplemented with penicillin (50U/ml)...
ORGANISM(S): Homo sapiens 
2008-11-01 | E-MEXP-1230 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Changes in TGF-β1 Differentiated and PGE2 Dedifferentiated Myofibroblasts
These data show that the genes that distinguish myofibroblasts from fibroblasts are myriad, and that some genes not traditionally associated with myofibroblast differentiation may serve as novel therapeutic targets for fibrosing disorders. Gene expression levels were assessed from total RNA on the A...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-63659 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Mus musculus BM-DCs upon stimulation by lung fibroblast conditioned medium or purified PGE2
To comprehensively understand how dendritic cells (DCs) are reprogrammed by lung fibroblasts- and their derived COX-2/PGE2, we employed lung fibroblasts isolated from WT or Ptgs2-/- mice, and collect their conditioned medium (CM) to stimulate the ex vivo cultured bone marrow (BM)-derived DCs (BM-DCs...
ORGANISM(S): Mus musculus 
2022-07-19 | E-MTAB-11873 | biostudies-arrayexpress
TranscriptomicsRNA-seq of BM neutrophils after treated with IL1b/IL6/PGE2
To investigate the effects of IL-1β/IL-6/PGE2 on neutrophil modulation, we performed RNA-seq to compare IL-1β/IL-6/PGE2-treated neutrophils to vehicle-treated neutrophils.
ORGANISM(S): Mus musculus 
2022-12-12 | E-MTAB-12367 | biostudies-arrayexpress
GenomicsEP4-Tg aortic VSMCs: Control vs PGE2
EP4-Tg aortic VSMCs: Control vs PGE2
PRJNA611821 | ENA
TranscriptomicsMicroarray analysis of the regulation of TNFalpha-stimulated PGE2 production in gingival fibroblasts
Prostaglandin E2 (PGE2) is involved in several inflammatory conditions including periodontitis. The aim of this study was to investigate the global gene expression profile of tumor necrosis factor alpha (TNFalpha) stimulated human gingival fibroblasts, focusing on signal pathways related to PGE2 pro...
ORGANISM(S): Homo sapiens 
2008-12-10 | E-GEOD-13903 | biostudies-arrayexpress
GenomicsATAC sequencing of murine NK cells treated with PGE2
ATAC sequencing of murine NK cells treated with PGE2
PRJNA1047609 | ENA
GenomicsATAC-seq of bone marrow neutrophil treated PGE2 or Vehicle
ATAC-seq of bone marrow neutrophil treated PGE2 or Vehicle
PRJNA821468 | ENA
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