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MetabolomicsPGM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation (Untargeted metabolomics)
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-03 | MTBLS15545 | MetaboLights
ProteomicsMitochondrial dysfunction is a driver of cardiac complications in PGM1-CDG with implications for therapy
Phosphoglucomutase 1 (PGM1) enzyme plays a central role in metabolism, by bridging glycolysis, glycogen metabolism and glycosylation. PGM1 deficiency is a rare congenital disorder of glycosylation (CDG) known for its unusually high incidence of lethal cardiac complications. While the role of PGM1 in...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD057756 | Pride
Human Glycosylation Multiomics Cardiomyocytes Cdg Lc-ms/ms 
ProteomicsThe type 1 diabetes (T1D) susceptibility gene PGM1 disrupts metabolic homeostasis in pancreatic beta cell in response to viral triggers: A new genetic-environmental mechanism in T1D
PGM1 is a type 1 diabetes (T1D) susceptibility gene that potentially plays a key role in regulating central carbon metabolism in -cells. Previous work suggested that -cell PGM1 transcription is lowered after Coxsackie B4 infection. Thus, we hypothesized that in response to viral triggers, decreased ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-22 | PXD074720 | Pride
T1d Pgm1 
ProteomicsAAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a new mouse model of inherited phosphoglucomutase 1 deficiency (PGM1-CDG)
PGM1 deficiency is recognized as the third most common N-linked Congenital Disorders of Glycosylation (CDG) in humans. Affected individuals present with liver, musculoskeletal, endocrine, and coagulation symptoms; however, the most life-threatening complication is an early onset of dilated cardiomyo...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD036271 | Pride
Pgm1-cdg Heart Glycoproteomics Mouse Proteomics 
UnknownCoagulation abnormalities and vascular complications are common in PGM1-CDG.
Not available
S-EPMC12682075 | biostudies-literature
UnknownNews on Clinical Details and Treatment in PGM1-CDG.
Not available
S-EPMC5580736 | biostudies-literature
UnknownOral D-galactose supplementation in PGM1-CDG.
Not available
S-EPMC5675745 | biostudies-literature
UnknownPGM1 suppresses colorectal cancer cell migration and invasion by regulating the PI3K/AKT pathway.
Not available
S-EPMC9134613 | biostudies-literature
UnknownThe Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG.
Not available
S-EPMC6506806 | biostudies-literature
UnknownIn Vitro Skeletal Muscle Model of PGM1 Deficiency Reveals Altered Energy Homeostasis.
Not available
S-EPMC10179458 | biostudies-literature
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