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ProteomicsCharacterization of a lipid-based jumbo phage compartment as a hub for early phage infection
Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles a protein-based phage nucleus to protect replicating phage DNA, but how it is protected prior to phage nucleus assembly...
ORGANISM(S): Pseudomonas aeruginosa PAO1-VE2 Pseudomonas phage phiKZ 
2024-11-26 | PXD049415 | Pride
Apms Pseudomonas aeruginosa Phage 
ProteomicsCharacterization of a lipid-based jumbo phage compartment as a hub for early phage infection
Viral genomes are most vulnerable to cellular defenses at the start of the infection. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles a protein-based phage nucleus to protect replicating phage DNA, but how it is protected prior to phage nucleus assembly...
ORGANISM(S): Pseudomonas aeruginosa PAO1-VE2 Pseudomonas phage phiKZ 
2024-11-26 | PXD050275 | Pride
Exploris 480 Phage Pseudomonas aeruginosa 
ProteomicsA phage nucleus-associated RNA-binding protein is required for jumbo phage infection
Large-genome bacteriophages (jumbo phages) of the Chimalliviriadae family assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and CRISPR/Cas nucleases. While the nuclear shell provides broad protection agains...
ORGANISM(S): Pseudomonas phage PhiPA3 Escherichia phage vB_EcoM_Goslar 
2024-03-25 | PXD045260 | Pride
Chimallin Mrna transport Whirly domain Jumbo phage 
ProteomicsIdentification of the bacteriophage nucleus protein interaction network
Here, we use proximity labeling and localization mapping to systematically identify proteins associated with the major nuclear shell protein chimallin (ChmA) and other distinctive structures assembled by these phages. We identify six uncharacterized nuclear shell-associated proteins, one of which di...
ORGANISM(S): Pseudomonas phage PhiPA3 
2024-01-26 | PXD041684 | Pride
Phage nucleus Miniturboid Phage 
ProteomicsDefining the essential genome of diverse phages with Phage Tn-seq
Phages are important drivers of bacterial evolution with therapeutic potential as antimicrobials. However, gaps in our understanding of phages and ability to rapidly engineer them with new genetic cargo hinders progress towards phage-based therapies. To address the lack of unbiased, genome-wide muta...
ORGANISM(S): Prodigiosinella confusarubida 
2026-07-30 | PXD072185 | Pride
Phage proteomics Phage transposon mutagenesis 
GenomicsA phage nucleus-associated RNA-binding protein required for jumbo phage infection
A phage nucleus-associated RNA-binding protein required for jumbo phage infection
PRJNA1019367 | ENA
TranscriptomicsA phage nucleus-associated RNA-binding protein required for jumbo phage infection
Large-genome bacteriophages (jumbo phages) of the Chimalliviriadae family assemble a nucleus-like compartment bounded by a protein shell that protects the replicating phage genome from host-encoded restriction enzymes and CRISPR/Cas nucleases. While the nuclear shell provides broad protection agains...
ORGANISM(S): Pseudomonas aeruginosa 
2024-03-12 | GSE243675 | GEO
UnknownA cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli.
Not available
S-EPMC9891218 | biostudies-literature
UnknownA phage nucleus-associated RNA-binding protein is required for jumbo phage infection.
Not available
S-EPMC11077065 | biostudies-literature
UnknownSelective transport of fluorescent proteins into the phage nucleus.
Not available
S-EPMC8191949 | biostudies-literature
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