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MetabolomicsComparative Transcriptome and Energy Metabolome Profiling Unravel the Key Role of GlcN6P Metabolic Pathway in Resistance against Bacteriophage in Enterotoxigenic Escherichia coli

The rapid emergence of phage-resistant bacterial mutants is a major challenge for phage application in the food industry. The resistance mechanisms of Enterotoxigenic E. coli (ETEC) against phage infection are largely unknown. In Escherichia coli, RapZ regulates gluc...

2025-12-15 | MTBLS13411 | MetaboLights
ProteomicsThe lactococcal phage p2 protein ORF47 impedes Lactococcus lactis MG1363 resistance to phage infection
The lactococcal phage p2 is a model for studying the Skunavirus genus, the most prevalent group of phages in cheese factories worldwide. It infects L. lactis MG1363, a model strain for the study of Gram-positive bacteria. The structural proteins of phage p2 have been thoroughly described. However, m...
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 Lactococcus phage 
2020-07-30 | PXD013186 | Pride
Lactococcus lactis Label-free quantification Mass spectrometry-based proteomics Phage infection 
ProteomicsA lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance
Bacterial pathogens are major causes of crop diseases, leading to significant production losses. For instance, kiwifruit canker, caused by the phytopathogen Pseudomonas syringae pv. actinidiae (Psa), has posed a global challenge to kiwifruit production. Treatment with copper and antibiotics, whilst ...
ORGANISM(S): Pseudomonas phage PaMx74 
2025-08-05 | PXD035071 | Pride
Psa phage proteomics Cryo-electron microscopy Phage biocontrol Structural proteome φpsa374 
MetabolomicsIntegrated analysis of therapeutic efficacy and resistance mechanisms of lytic phages targeting ST218 K57 CR-hvKp
Clinical infection caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually increasing and spreading across the world, and phage therapy is a viable application as an alternative to antibiotics. However, additional clinical application is still restricted by the phag...
2025-09-18 | MTBLS12480 | MetaboLights
ProteomicsInvestigating Lactococcus lactis MG1363 response to phage p2 infection at the proteome level
Phages are viruses that specifically infect and kill bacteria. Bacterial fermentation and biotechnology industries see them as enemies, however, they are also investigated for the treatment or prevention of infections caused by multidrug resistant bacteria. Whether foes or allies, their importance i...
ORGANISM(S): Lactococcus lactis subsp. cremoris MG1363 Lactococcus phage 
2019-01-29 | PXD011263 | Pride
Genome editing Lactococcus lactis Label-free quantification Mass spectrometry-based proteomics Phage infection 
TranscriptomicsGenomic and gene-expression comparisons among phage-resistant type-IV pilus mutants of Pseudomonas syringae pathovar phaseolicola
Pseudomonas syringae pv. phaseolicola (Pph) is a significant bacterial pathogen of agricultural crops, and phage Φ6 and other members of the dsRNA virus family Cystoviridae undergo lytic (virulent) infection of Pph, using the type IV pilus as the initial site of cellular attachment. Despite the pop...
ORGANISM(S): Pseudomonas syringae pv. phaseolicola 
2016-03-15 | E-MTAB-4053 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium definitive phage type 104 (DT104) isolates
Salmonella enterica serovar Typhimurium (S. Typhimurium) definitive phage type 104 (DT104) has caused significant morbidity and mortality in humans and animals for almost three decades. We have completed the full DNA sequence of one DT104 strain, NCTC13348 and show that the main differences between ...
ORGANISM(S): Salmonella enterica 
2008-09-05 | E-MTAB-20 | biostudies-arrayexpress
MetabolomicsHfq Regulates Efflux Pump Expression and Purine Metabolic Pathway to Increase the Trimethoprim Resistance in Aeromonas veronii

Aeromonas veronii (A. veronii) is a zoonotic pathogen. It causes clinically a variety of diseases such as dysentery, bacteremia, and meningitis. And it also brings huge losses to aquaculture. A. veronii has been documented as a multiple antibiotic resistant bacterium. Hfq (host factor for RNA bac...

2020-02-19 | MTBLS1411 | MetaboLights
ProteomicsCarbohydrates and the oxidative branch of the pentose phosphate pathway modify Bacteroides thetaiotaomicron phage resistance by phase variable S-layers
The human gut microbiota consists of hundreds of bacterial species, some of which persist in the presence of lytic phage that infect them. Bacteroides employ numerous phase-variable strategies to survive in the presence of phage, including capsular polysaccharides (CPS) and S-layer lipoproteins. We ...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) 
2025-08-22 | PXD063111 | Pride
Phage Bacteroides Surface layer 
ProteomicsThe component parts of bacteriophage virions accurately defined by a new machine-learning approach built on evolutionary features.
Klebsiella pneumoniae has risen to prominence as a major threat to human health, with hypervirulent and drug-resistant lineages spreading globally. Given their antimicrobial resistant phenotypes, new therapies are required for the treatment of these infections, and bacteriophages (phages) that kill ...
ORGANISM(S): Klebsiella phage ST405-OXA48phi1.1 
2021-04-30 | PXD020607 | Pride
Phage Prediction Machine learning 
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