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TranscriptomicsEffect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
The nuclear receptors CAR (constitutive androstane receptor) and PXR (pregnane X receptor) mediate the effects of phenobarbital (PB) on gene transcription. To investigate the relative role of CAR and PXR in the induction response, cDNA arrays were generated containing 120 genes which are known to b...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12489 | biostudies-arrayexpress
TranscriptomicsPhenobarbital and TCPOBOP effects on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis
This SuperSeries is composed of the following subset Series: GSE12489: Effect of phenobarbital on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis GSE12509: Effect of TCPOBOP on CAR and PXR regulated genes involved in drug metabolism and cholesterol homeostasis Ref...
ORGANISM(S): Mus musculus 
2008-08-23 | E-GEOD-12529 | biostudies-arrayexpress
TranscriptomicsPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice.
This SuperSeries is composed of the following subset Series: GSE34423: Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice [Expression array]. GSE34462: Phenobarbital mediates an epigenetic switch at the constituti...
ORGANISM(S): Mus musculus 
2011-12-16 | E-GEOD-34463 | biostudies-arrayexpress
TranscriptomicsDiet and phenobarbital affect cholesterol homeostasis and drug metabolism
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were analyzed using Sterolgene v0 cDNA microarrays. Sterolgene microarray is a tool designe...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-6447 | biostudies-arrayexpress
TranscriptomicsPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice [Expression array].
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest st...
ORGANISM(S): Mus musculus 
2011-12-14 | E-GEOD-34423 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with phenobarbital and fed a high cholesterol diet an
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A. Experiment Overall Design: One group of mic...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6721 | biostudies-arrayexpress
TranscriptomicsMicroarray experiment to identify gene expression changes in response to Phenobarbital treatment and CncC overexpression in Drosophila.
Transcriptional profiling of mature adult w1118 males treated with phenobarbital compared to controls and heat treated HS-CncC flies compared with heat treated w1118 flies. Mature adult w1118 males were treated witheither 5% sucrose alone or 5% sucrose supplemented with 0.3% phenobarbital for six ho...
ORGANISM(S): Drosophila melanogaster 
2011-11-29 | E-GEOD-30087 | biostudies-arrayexpress
GenomicsChanges in histone modifications H3K4me2, H3k27me3 and H3K36me3 due to phenobarbital in mice
29-32 days old male mice where either treated with Phenobarbital or untreated Replicated control/treated study with IP and Input per group and antibody
ORGANISM(S): Mus musculus 
2012-11-10 | E-GEOD-41399 | biostudies-arrayexpress
ProteomicsThe alterations of proteins expression related to insulin signaling pathway in the brain of phenobarbital addictive rats by TMT
Drug addiction is a chronic relapsing brain disease. The alterations of glucose uptake and metabolism were found in the brain of drug addicts. Insulin mediates brain glucose metabolism and its abnormality could induce brain injury and cognitive impairment. Here, we established a rat model of phenoba...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-10-29 | PXD021101 | Pride
Addiction Tmt Insulin signaling pathway Phenobarbital Proteomics 
TranscriptomicsExpression differences related to phenobarbital feeding in worker honey bees
The drug phenobarbital induces cytochrome P450 monooxygenase (P450) gene expression in many animals, but no changes in P450 expression, or expression of any detoxification genes, were observed in worker honey bees fed on phenobarbital-candy relative to bees fed plain candy. Keywords: Expression pro...
ORGANISM(S): Apis mellifera 
2012-05-11 | E-GEOD-34029 | biostudies-arrayexpress
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