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ProteomicsImpact of whole-body versus nose-only exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE-/- mouse model [Lung data]
The objective of this study was to compare the biological and toxicological response of apolipoprotein E-deficient (Apoe-/-) mice to 3R4F mainstream smoke exposure for 2 months in whole-body exposure chambers (WBEC) and nose-only exposure chambers (NOEC). Female ApoE-/- mice were randomized into fou...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-26 | PXD018185 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsA 7-month e-vapor aerosol inhalation toxicology study in C57BL/6 mice [Lung data]
A 7-month inhalation study in C57BL/6 mice was conducted to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation or switching to an e-vapor product after 3 months of exposure to 3R4F cigarette smoke (CS). In this study,...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-31 | PXD019918 | Pride
Lc-msms Mouse Lung Systems toxicology Itraq 
ProteomicsFasciola hepatica cathepsin L zymogens: immuno-proteomic evidence for highly immunogenic zymogen-specific conformational epitopes to support diagnostics development
We conducted immuno-proteomic investigations of recombinant and native procathepsins ((r)FhpCL1) and counterpart polyclonal antibodies to a recombinant mutant procathepsin L (anti-rFhΔpCL1). Proteomics including gel electrophoresis and liquid chromatography tandem mass spectrometry were used for for...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2022-07-19 | PXD030293 | Pride
Triclabendazole. Recombinant Fasciolosis Cathepsin Diagnostics 
TranscriptomicsRapid evolution of phenotypic plasticity and shifting thresholds of genetic assimilation in the nematode Caenorhabditis remanei
Many organisms can acclimate to new environments through phenotypic plasticity, a complex trait that can be heritable, subject to selection, and evolve. However, the rate and genetic basis of plasticity evolution remain largely unknown. We experimentally evolved outbred populations of the nematode C...
ORGANISM(S): Caenorhabditis remanei 
2014-05-04 | E-GEOD-56510 | biostudies-arrayexpress
UnknownWithdrawn: Precision Neoantigen Discovery Using Large-scale Immunopeptidomes and Composite Modeling of MHC Peptide Presentation.
Not available
S-EPMC8318994 | biostudies-literature
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951 (part 6)
Background: Intrinsic glioma subtypes (IGS) are molecularly similar tumors that can be identified based on unsupervised gene-expression analysis. Here, we have evaluated the clinical relevance of these subtypes within EORTC26951, a randomized phase III clinical trial investigating adjuvant procarbaz...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43353 | biostudies-arrayexpress
UnknownThe design of schistosomiasis monitoring and evaluation programmes: The importance of collecting adult data to inform treatment strategies for Schistosoma mansoni.
Not available
S-EPMC6175503 | biostudies-literature
TranscriptomicsIntrinsic glioma subtypes in EORTC 26951
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43388 | biostudies-arrayexpress
UnknownFasciola hepatica Cathepsin L Zymogens: Immuno-Proteomic Evidence for Highly Immunogenic Zymogen-Specific Conformational Epitopes to Support Diagnostics Development.
Not available
S-EPMC9361350 | biostudies-literature
ProteomicsPilot evaluation of two Fasciola hepatica biomarkers for supporting TCBZ efficacy diagnostics
Two Fasciola hepatica biomarkers, calreticulin and triose phosphate isomerase, of prospective diagnostic potential were recombinantly expressed and analysed through gel-based proteomics and liquid chromatography and tandem mass spectrometry (LC-MS/MS). Formal identifications through tandem mass spec...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2020-07-31 | PXD017848 | Pride
Diagnostics Triclabendazole Anthelmintic efficacy Liver fluke Proteomics Biomarkers Recombinant protein 
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