Sort   by:  
 Page size 
ProteomicsSubstrate selectivity for semisynthetic CK2 proteins with Pin1
Protein Ser/Thr kinase CK2 is involved in a myriad of cellular processes including cell growth and proliferation by phosphorylating hundreds of substrates, yet the regulation process of CK2 function is poorly understood. The CK2 catalytic subunit, CK2α, is phosphorylated at Thr344 and phosphorylati...
ORGANISM(S): synthetic construct 
2011-10-24 | E-GEOD-33150 | biostudies-arrayexpress
TranscriptomicsNon-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2
A synthetic analog of sphingosine named FTY720 (Fingolimod), phosphorylated by sphingosine kinase-2, interacts with sphingosine-1-phosphate (S1P) receptors expressed on various cells. FTY720 suppresses the disease activity of multiple sclerosis (MS) chiefly by inhibiting S1P-dependent egress of auto...
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28642 | biostudies-arrayexpress
ProteomicsPhytophthora capsici Phosphorylated Proteomics
To identify phosphorylated proteins in wild-type and Dicer-like 1 gene deficient mutant of Phytophthora capsici.
ORGANISM(S): Phytophthora capsici 
2024-03-26 | PXD038523 | Pride
Phosphorylated proteins Phytophthora capsici 
GenomicsRole of Polycomb group proteins in the DNA damage response – a reassessment
We have investigated whether components of Polycomb repressive complex 1 (PRC1) are recruited to double-strand breaks (DSBs) generated by inducible expression of the AsiSI restriction enzyme in normal human fibroblasts. Using chromatin immunoprecipitation and deep sequencing (ChIP-seq), which detec...
ORGANISM(S): Homo sapiens 
2014-07-06 | E-GEOD-55605 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of yeast to determine genome-wide occupancy profiles for RNA polymerase (Pol) II, its phosphorylated forms, and transcription factors
To investigate the chromatin transcription cycle, we determined genome-wide occupancy profiles for RNA polymerase (Pol) II, its phosphorylated forms, and transcription factors in growing yeast. ChIP-chip was performed to identify the genomic binding locations for Rpb3, TFIIB, Tfg1, Kin28, Cet1, Spt4...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-23 | E-TABM-1033 | biostudies-arrayexpress
ProteomicsPhosphorylated Tau Interactome in the Human Alzheimers Disease Brain
Accumulation of phosphorylated tau is a key pathological feature of Alzheimers disease. Phosphorylated tau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles. The pathological actions of phosphorylated tau are mediated by surrounding neuronal prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-17 | MSV000085305 | MassIVE
ProteomicsHCV Hypo- vs. Hyper-Phosphorylated NS5A Interactome
Chronic hepatitis C virus (HCV) infection is a leading cause of liver cancer. HCV propagation and oncogenicity depend in part on the phosphorylation states of its non-structural protein 5A (NS5A); however, little is known about how hypo- or hyper-phosphorylated NS5A functions. Here, we segregated hy...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD012767 | Pride
Cancer Antiviral Ns5a Liver Hcv 
ProteomicsAnalysis of phosphorylated proteins in ATP6V1G1 overexpressed hepatoma cells
To investigate the biological functions of ATP6V1G1 related proteins with overexpression and phosphorylation changes in hepatocellular carcinoma cells
ORGANISM(S): Homo Sapiens 
PXD055721 |
TranscriptomicsHDACs and Phosphorylated Pol II CTD recruit Spt6 for cotranscriptional histone reassembly
Spt6 is a multifunctional histone chaperone involved in the maintenance of chromatin structure during elongation by RNA polymerase II (Pol II). Spt6 has a tandem SH2 (tSH2) domain within its C-terminus that recognizes Pol II CTD peptides phosphorylated on Ser2, Ser5 or Try1 in vitro. Deleting the tS...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-25 | E-GEOD-61713 | biostudies-arrayexpress
ProteomicsThe interactome of tau phosphorylated at T217 in Alzheimers disease human brain tissue
Tau phosphorylation and aggregation are pathological features of Alzheimers disease. Tau phosphorylated at threonine 217 (pT217) and threonine 231 (pT231) are early fluid biomarkers of Alzheimers disease, suggesting early involvement in disease. However, little is known about the specific actions of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-11 | MSV000096377 | MassIVE
Sort   by:  
 Page size