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ProteomicsSoDA-PAL Protein Profiling Proteomics of Sorgoleone Catabolizing Microbial Isolate Acinetobacter pittii SO1
Photoaffinity probe-based protein labeling of microbial isolate Acinetobacter pittii SO1 (NCBITAXON:48296), isolated from the sorghum rhizosphere that can utilize sorgoleone as a sole carbon source in order to identify proteins that bind sorgoleone. Photoaffinity labeling of A. pittii lysates using ...
ORGANISM(S): Acinetobacter Pittii (ncbitaxon:48296) 
2023-05-18 | MSV000091986 | MassIVE
ProteomicsPhotoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Cystic fibrosis (CF) pharmacological correctors such as VX-445 are used in combinations as highly effective modulator therapy (HEMT) at CF clinics due to their efficacy in improving Cystic Fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Yet, several side-effects...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD060898 | Pride
Elexacaftor Cystic fibrosis (cf) Vu439 Click chemistry Target identification Cystic fibrosis transmembrane conductance regulator (cftr) Off-target Mass spectrometry (ms) Proteomics Diazirine Metabolomics Chemoproteomics Corrector Photoaffinity ligand (pal) Vx-445 Saccharopine dehydrogenase-like oxidoreductase (sccpdh) 
UnknownPhotoaffinity Labeling of the Human A2A Adenosine Receptor and Cross-link Position Analysis by Mass Spectrometry.
Not available
S-EPMC5467184 | biostudies-literature
UnknownPhotoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target.
Not available
S-EPMC12281486 | biostudies-literature
ProteomicsEnd-to-end Throughput Chemical Proteomics for Photoaffinity Labeling Target Engagement and Deconvolution
Photoaffinity labeling (PAL) methodologies have proven to be a critical tool for the unbiased deconvolution of protein-ligand binding events in complex biological systems. However, like other chemical proteomic workflows, it is limited by time-intensive sample manipulations and data acquisition tech...
ORGANISM(S): Homo sapiens (Human) 
2024-10-08 | PXD054514 | Pride
Immortalized cell lines Orbitrap fusion lumos Human 
UnknownPhotoaffinity labeling of protein targets in a complex metazoan: proof-of-concept using a probe for <i>Schistosoma mansoni</i> tubulin.
Not available
S-EPMC12632543 | biostudies-literature
ProteomicsMicroMap photoproximity labeling enables small molecule binding site mapping
Proteomics data for MicroMap enabled binding site mapping
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-26 | MSV000092043 | MassIVE
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
Structural characterization of small molecule binding site hotspots within the global proteome is uniquely enabled by photo-affinity labeling (PAL) coupled with chemical enrichment and unbiased analysis by mass spectrometry (MS). MS-based binding site hotspot maps provide structural resolution of in...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD013420 | Pride
Photo-affinity labeling Natural product Structural proteomics 
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
PRIDE > Archive > PXD013420 Project PXD013420 Download Project Files Summary Title A binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics Description Structural characterization of small molecule binding site hotspo...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD014283 | Pride
Photo-affinity labeling Structural proteomics 
UnknownμMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping.
Not available
S-EPMC10809032 | biostudies-literature
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