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UnknownDesign, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
Not available
S-EPMC3401313 | biostudies-literature
ProteomicsChemical proteomics with novel fully functionalized fragments and stringent target prioritization identifies the glutathione-dependent isomerase GSTZ1 as a lung cancer target
Photoreactive fragment-like probes have been applied to discover target proteins that constitute novel cellular vulnerabilities and to identify viable chemical hits for drug discovery. Through forming covalent bonds, functionalized probes can achieve stronger target engagement and require less effor...
ORGANISM(S): Homo sapiens (Human) 
2024-04-05 | PXD035201 | Pride
Photoreactive probes Lung cancer Gstz1 Chemical proteomics 
UnknownAppendage- and Scaffold-Diverse Electrophilic and Photoreactive Probes for Integrated Phenotypic Screening-Target Identification Campaigns via a Minimalist Bifunctional Isocyanide.
Not available
S-EPMC11483914 | biostudies-literature
ProteomicsActivity-based protein profiling in human M2 macrophages using DHA-based photoaffinity probes
17-Hydroxydocosahexaenoic acid (17-HDHA), an oxidative metabolite of the fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3), is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the biological effect of 17-HDHA are poorly understood. Here, we report the ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-28 | PXD027600 | Pride
Human Abpp Photoaffinity Macrophage 
ProteomicsMapping Protein Targets of Bioactive Small Molecules using Lipid-Based Chemical Proteomics
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes combined with quantitative mass spectrometry to globally map lipid-protein interactions, and the effects of drugs on these interactions, in cells. ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-26 | PXD007570 | Pride
Hek293t Neuro2a Orbitrap velos Chemoproteomics Lipid probes 
UnknownAnalysis and Identification of Tumorigenic Targets of MicroRNA in Cancer Cells by Photoreactive Chemical Probes.
Not available
S-EPMC7073161 | biostudies-literature
ProteomicsDevelopment of nucleus-targeted synthetic histone photoaffinity probes
Dissection of the physiological interactomes of histone post-translational modifications (hPTMs) is crucial for understanding fundamental epigenetic regulatory pathways. Current peptide- or protein-based histone photoaffinity probes have greatly expanded the ability to probe the epigenetic interacto...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD045620 | Pride
Nucleus-targeted histone photoaffinity probe Lactylation The epigenetic interactome Hard-to-transfect cells Native cells 
UnknownClickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().
Not available
S-EPMC3378062 | biostudies-literature
ProteomicsChemical tools to expand the ligandable proteome: elaborated fragment-based photoreactive stereoprobes
Efforts to expand the ligandable proteome have explored stereochemically defined fragments equipped with photoreactive and clickable handles (photo-stereoprobes) for mapping reversible small molecule-protein interactions in living systems. Here, we investigate the impact of structural elaboration of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD052692 | Pride
Proteomics Chemical biology 
UnknownDesign and synthesis of a clickable, photoreactive amino acid p-(4-(but-3-yn-1-yl)benzoyl)-l-phenylalanine for peptide photoaffinity labeling.
Not available
S-EPMC9811243 | biostudies-literature
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