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ProteomicsUnbiased identification of the liposome protein corona using photoaffinity based chemoproteomics
Determination of protein adsorption to the surface of a nanoparticle determined by photoaffinity based chemoproteomics.
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD016229 | Pride
Chemoproteomics photoaffinity labelling human serum protein corona 
GenomicsComparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
Comparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
PRJNA1416391 | ENA
GenomicsChemotranscriptomic Profiling with a Thiamine Monophosphate Photoaffinity Probe
Chemotranscriptomic Profiling with a Thiamine Monophosphate Photoaffinity Probe
PRJNA1160294 | ENA
TranscriptomicsComparative Analysis of Alkyne- and Desthiobiotinylated Photoaffinity Probes for Chemotranscriptomic Profiling
Understanding small molecule-RNA interactions is a crucial part in drug development and fundamental biology. Chemotranscriptomic profiling is emerging as a powerful platform to interrogate interactions of small molecules with entire transcriptomes. This technique relies on photoaffinity probes that ...
ORGANISM(S): Escherichia coli 
2026-03-18 | GSE318057 | GEO
ProteomicsProteome-wide profiling of olaparib interactors using a biotinylated photoaffinity probe
Olaparib is a widely used PARP inhibitor for the treatment of BRCA-mutated cancers. To comprehensively understand the drug's clinical impact, measuring its interactions with intended on- and off-targets is crucial. In this study, olaparib's on- and off-targets were profiled using photoaffinity label...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD060372 | Pride
Parp inhibitors Photoaffinity labeling Chemical proteomics Olaparib 
ProteomicsDesign and evaluation of a cyclobutane diazirine alkyne tag for photoaffinity labeling in cells
Alkyl diazirines are frequently used in photoaffinity labeling to trap and identify small molecule–protein interactions. How-ever, the alkyl diazirine can preferentially label acidic amino acids and acidic protein surfaces in a pH-dependent manner, presumably via a long-lived alkyl diazo intermediat...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD035954 | Pride
Cereblon Diazirine Thalidomide Photoaffinity labeling Binding site mapping 
Proteomicsphotoaffinity for Puerarin and mouse brainstem
To elucidate the molecular mechanism mediating the inactivated effect of DMV neurons on fat absorption, we performed an activity-based protein profiling strategy, using Puerarin as a “bait”. The Puerarin-tag probe was synthesized with a photoreactive tag to enrich and visualize target proteins via a...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-06 | PXD052140 | Pride
Puerarin brainstem 
GenomicsPEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions
PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions
PRJNA657425 | ENA
OtherPEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions
RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of methods for the analysis of small molecule-RNA interactions. Here we present our efforts to develop such a pl...
ORGANISM(S): Homo sapiens Synthetic plasmid 
2020-08-17 | GSE156312 | GEO
ProteomicsProteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors
Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Selectivity may be evaluated against a panel of kinases, or – preferred – in a complex proteome. Probes that allow photoaffinity-labeling of their targets can facilitate this process. Here,...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD053278 | Pride
Kinase inhibitors Imidazopyrazines Photoaffinity labeling 
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