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TranscriptomicsTranscription profiling of mouse wild type and Pias1 null cells in response to IFN treatments to study the effect of PIAS1 on interferon (IFN) signaling pathway
Microarray analysis was designed to study the effect of PIAS1 on interferon (IFN) signaling pathway by comparing the gene activation profiles of wild type and Pias1 null cells in response to IFN treatments. Microarray analysis was performed essentially following the manufacturer's instructions (Affy...
ORGANISM(S): Mus musculus 
2007-10-10 | E-GEOD-1552 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of PIAS1 on AR gene expression in MDA-MB453
The majority of breast cancer subtypes express androgen receptor (AR) in addition to estrogen receptor α (ERα). Depending on the breast cancer subtype androgen signaling has either stimulatory or inhibitory roles in breast cancer cell growth. We have mapped AR cistrome in ERα negative human molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-70162 | biostudies-arrayexpress
TranscriptomicsEffect of PIAS1 on gene expression
To study the effect of PIAS1 on transcriptional regulation, we establishedstable PIAS1 shRNA knockdown cells in breast cancer cell line MDA-MB231. By comparing the expression profiles of control vs PIAS1 knockdown cells, we can identify potential PIAS1 target genes involved in breast tumorigenesis. ...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-44024 | biostudies-arrayexpress
ProteomicsQuantitative proteomics identifies novel PIAS1 protein substrates involved in cell migration and motility
The Protein Inhibitor of Activated STAT 1 (PIAS1) is an E3 SUMO ligase that plays important roles in various cellular pathways, including STAT signaling, p53 pathway, and the steroid hormone signaling pathway. PIAS1 can SUMOylate PML (at Lys-65 and Lys-160) and PML-RARα promoting their ubiquitin-med...
ORGANISM(S): Homo sapiens (Human) 
2020-02-06 | PXD011932 | Pride
Pias1 Vimentin Cell invasion Sumoylation Quantitative proteomics 
TranscriptomicsGenome-wide analysis of the effect of PIAS1 knockdown by siRNA on the androgen regulated gene programs
Analysis of PIAS1 co-regulation in the androgen signaling pathways in prostate cancer cell line. VCaP cells were exposed to control (siSCR) or PIAS1 (siPIAS1) targeted siRNA for 96h. After 16h of 100 nM testosterone (or without) treatment the total RNA was isolated, each treatment included three rep...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-30316 | biostudies-arrayexpress
TranscriptomicsEffect of PIAS1 on gene expression
To study the effect of PIAS1 on transcriptional regulation, we establishedstable PIAS1 shRNA knockdown cells in breast cancer cell line MDA-MB231. By comparing the expression profiles of control vs PIAS1 knockdown cells, we can identify potential PIAS1 target genes involved in breast tumorigenesis.
ORGANISM(S): Homo sapiens 
2014-02-06 | GSE44024 | GEO
GenomicsEBNA1 SUMOylation by PIAS1 Suppresses EBV Lytic Replication and Enhances Episome Maintenance
EBNA1 SUMOylation by PIAS1 Suppresses EBV Lytic Replication and Enhances Episome Maintenance
PRJNA1310941 | ENA
GenomicsPIAS1 is a target gene selective androgen receptor coregulator in prostate cancer cell chromatin
To study the importance of PIAS1 (protein inhibitor of activated STAT1) for the androgen-regulated transcriptome of VCaP prostate cancer cells, we silenced its expression by RNAi. Transcriptome analyses revealed that a subset of the androgen-regulated genes is significantly influenced, either activa...
ORGANISM(S): Homo sapiens 
2015-01-02 | GSE56086 | GEO
GenomicsMulti-omics integration identifies progenitor-state specific PBRM1-PIAS1 cooperation in repressing differentiation in epithelial tissue
Multi-omics integration identifies progenitor-state specific PBRM1-PIAS1 cooperation in repressing differentiation in epithelial tissue
PRJNA948849 | ENA
GenomicsA UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection
A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection
PRJNA1103198 | ENA
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