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Transcriptomicscelecoxib-treated vs control breast tumours
Biopsies and surgical specimens were obtained from breast tumours treated and non-treated with celecoxib 400mg twice daily for 2 weeks
ORGANISM(S): Homo sapiens 
2013-03-28 | E-MTAB-566 | biostudies-arrayexpress
ProteomicsIdentifying the N-terminus of SLX4Nter in HeLa KO30 cells
The project was aimed at identifying the N-terminus of a truncated form of SLX4 (termed SLX4Nter) in HeLa KO30 cells. The HeLa KO30 cell line comes from a clone of HeLa Flp-In T-Rex cells (termed FITo) obtained through a CRISPR-Cas9 approach using commercially available plasmids from Santa Cruz Biot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD029062 | Pride
Crispr-cas9 Slx4 N-terminus acetylation N-terminal truncation 
TranscriptomicsGene expression changes associated with progression of Irf8M-bM-^@M-^S/M-bM-^@M-^S CML-like disease into blast crisis after M-NM-2-catenin activation
Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics, we observed that compound constitutive activation of M-NM-2-catenin and deletion of Irf8 results in progression of CML-like disease into fatal bla...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-49054 | biostudies-arrayexpress
TranscriptomicsThe dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis
Sertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately with developing germ cells. They not only provide physical and nutritional support but also secrete factors essential to the complex developmental processes of germ cell proliferation and differentiation. T...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-59698 | biostudies-arrayexpress
UnknownLow serum DHEA-S is associated with impaired lung function in women.
Not available
S-EPMC7280766 | biostudies-literature
TranscriptomicsAge-Associated Loss of Lymphatic Vessels Promotes Cardiac Inflammation (sc-RNA-SEQ)
Aging is a major risk factor for cardiovascular diseases, yet the contribution of the lymphatic vasculature to cardiac aging remains largely unexplored. Here, we show that aging reduces lymphatic vessel density in human and mice hearts and induces morphological changes, including the formation of zi...
ORGANISM(S): Mus musculus 
2026-08-14 | E-MTAB-17510 | biostudies-arrayexpress
UnknownMutations in PIGS, Encoding a GPI Transamidase, Cause a Neurological Syndrome Ranging from Fetal Akinesia to Epileptic Encephalopathy.
Not available
S-EPMC6174287 | biostudies-literature
GenomicsDistribution of total histone variants H3.1 and H3.3 in pluripotent mouse embryonic stem cells (mESCs) and in vitro differentiated neuronal precursor cells (NPCs)
We profiled the enrichment of the replicative H3.1 and non-replicative H3.3 histone variants using the SNAP-seq assay previously developed in the team (Gatto et al., 2022, Forest et al., 2023). We used KH2 mouse embryonic stem cells (mESCs) bearing doxycycline-inducible H3.1/H3.3-SNAP, which were ex...
ORGANISM(S): Mus musculus 
2025-04-24 | E-MTAB-14240 | biostudies-arrayexpress
UnknownSrf controls satellite cell fusion through the maintenance of actin architecture.
Not available
S-EPMC5800804 | biostudies-literature
ProteomicsProteomic comparisons of autophagy mutant, salicylic acid defiscient mutant and wild type plants grown in ideal nutrition and in low nitrate and low sulfate conditions.
Genotypes used are Arabidopsis thaliana (L.) Col-0 wild-type, atg5.3 mutant (SALK_020601), sid2.2 (Dewdney et al., 2000) and the atg5.3/sid2.2 double mutant that has been previously characterized by Yoshimoto et al. Plant Cell (2009). Plants were cultivated under control conditions (ideal nutriti...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-10-27 | PXD029638 | Pride
Atg5 Autophagy Sulfate Sid2 Nitrate 
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