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TranscriptomicsTranscriptional profiling of autophagy proficient and compromised cell lines, determined by expression levels of Atg5
Autophagy is activated in pancreatic ductal adenocarcinoma (PDAC) and is currently being considered a promising therapeutic target in clinical trials. PDAC is a highly lethal disease with incidence rate equalling mortality rate. Main reasons for PDAC lethality are late-stage diagnosis, high agressiv...
ORGANISM(S): Mus musculus 
2018-10-15 | E-MTAB-6275 | biostudies-arrayexpress
TranscriptomicsIdentification Atg5-related microRNAs involved in the regulation of tumor formation
Autophagy plays an important role in physiology and tumorigenesis. We and others have demonstrated that Ha-ras overexpression induces autophagy in NIH3T3 cells. Autophagic machinery is regulated by a family of autophagy associated genes (Atg). The inducible Ha-ras oncogene was introduced into mouse ...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-38911 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse colonic goblet cells deficient in Atg5
Purpose of this experiment was to gain insight into the transcriptional changes resulting from Atg5 deficiency in colonic goblet cells.
ORGANISM(S): Mus musculus 
2010-09-30 | E-TABM-815 | biostudies-arrayexpress
ProteomicsEffect of ATG5 depletion on virus infection
Proteome analysis of wild-type and atg5-/- mouse embryonic fibroblasts infected with Japanese encephalitis virus
ORGANISM(S): Mus musculus (Mouse) Japanese encephalitis virus group 
2019-10-22 | PXD014986 | Pride
Atg5 Autophagy Japanese encephalitis virus Mouse embryonic fibroblasts 
TranscriptomicsExpression in IFN-gamma treated control and Atg5-/- macrophages
Type-I (α/β) and -II (γ) interferons (IFN), through an incompletely understood combination of redundant and unique mechanisms, are essential for host resistance to viral infection. We report a requirement for the Atg5-Atg12/Atg16L1 autophagosome elongation complex in IFNγ-mediated control of murine ...
ORGANISM(S): Mus musculus 
2012-01-05 | E-GEOD-34863 | biostudies-arrayexpress
TranscriptomicsImpact of conditional autophagy knockout on cytotoxic CD8 T cells at day 7 and day 8 after influenza infection
To investigate the role of autophagy on cytotoxic CD8 T cells, we developed a new mouse that expresses an Atg5 gene with loxP sites up- and downstream of the exon 3, Cre-recombinase, T cell receptor specific for the OVA peptide SIINFEKL and the congenic marker Thy1.1. These cells were adoptively tra...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-49254 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of ATG5 induced hepatocellular carcinoma in zebrafish
Transcriptomic analysis of ATG5 induced hepatocellular carcinoma in zebrafish
PRJNA1165792 | ENA
ProteomicsGlobal analysis of impact of Atg5 mutation on steady-state protein levels
This experiment analyzes the global impact of Atg5-/- mutation on steady-state protein levels by a standard SILAC experiment. WT+vector cells were grown in isotopically labeled media for multiple passages in order to fully label the proteome. Unlabeled Atg5-/- cells and labeled WT+vector cells were ...
ORGANISM(S): Homo sapiens (Human) 
2016-06-14 | PXD003558 | Pride
Steady state protein level Atg5 Human primary fibroblasts 
GenomicsGenome-wide expression analysis in Control and Atg5-deficient eosinophils.
Genome-wide expression analysis in Control and Atg5-deficient eosinophils.
PRJNA1026988 | ENA
ProteomicsVAMP7 KO and ATG5 KO in axonal growth
VAMP7 is involved in autophagy and in exocytosis mediating neurite growth, two yet unconnected cellular pathways. Here we found that nutrient restriction and activation of autophagy stimulated axonal growth while inhibition led to multiple axons. VAMP7 KO neuronal cells showed impaired whereas ATG5 ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-03-29 | PXD020502 | Pride
Secretion Neurons Vamp7 Amphisomes Axonal growth 
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