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MetabolomicsA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using forced desynchrony increases cardiovascular risk factors in humans. Here we integrated data ...
2018-05-16 | MTBLS656 | MetaboLights
GenomicsAutozygosity pilot Born in Bradford
The offspring of first cousin marriages have ~6% of their genome autozygous, i.e. homozygous identical by descent, or even more if there was further consanguinity in their ancestry. In the UK there are large populations with very high first cousin marriage rates of 20-50%. Sequencing the exomes of...
EGAS00001000462 | EGA
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42423 | biostudies-arrayexpress
OtherRefined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome.
Data from ProteomeXchange, PXD ID: PXD001180. File: tio2_250ug.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):500-7 . From the Abstract: {{i}} Here, we report a pilot investigation of AD phosphoproteome by titanium dioxide enrichment coupled with high resolution LC-MS/MS. During the optimi...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210034774 | GPMDB
Resource Reanalysis 
UnknownA Pilot Study to Evaluate Neurodevelopmental Outcomes in a Pediatric Cohort With Genodermatoses.
Not available
S-EPMC12458098 | biostudies-literature
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs.
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44265 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42424 | biostudies-arrayexpress
UnknownA novel group parenting intervention to reduce emotional and behavioural difficulties in young autistic children: protocol for the Autism Spectrum Treatment and Resilience pilot randomised controlled trial.
Not available
S-EPMC6597639 | biostudies-literature
UnknownEvaluating the feasibility of a decision aid to promote shared decision making among young adults with first-episode psychosis: protocol for a pilot study.
Not available
S-EPMC7798319 | biostudies-literature
UnknownMultimorbidity rehabilitation versus disease-specific rehabilitation in people with chronic diseases: a pilot randomized controlled trial.
Not available
S-EPMC6267787 | biostudies-literature
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