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ProteomicsA distinctive form of mitochondrial anaerobic respiration in somatic stem cells
In this project investigates how cells survive and proliferate in the absence of oxygen and/or under nutrient-limited conditions. We focus on the metabolic rewiring underlying this adaptation, which is characteristic of stem cells but absent in differentiated cells. We also examine whether this mech...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD072954 | Pride
Metabolism Ischemia Mesenchymal stem cells Anoxia Mitochondria 
ProteomicsDHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance
Dihydroorotate dehydrogenase (DHODH), a key enzyme in de novo pyrimidine biosynthesis, has recently emerged as a therapeutic target in various cancers. We have previously identified a pivotal role of DHODH in initiation of cutaneous squamous cell carcinoma (cSCC), the second most common type of non-...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD070860 | Pride
Cscc Cutaneous squamous cell carcinoma Differentiation Pyrimidine biosynthesis Cancer therapy Dhodh 
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