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UnknownPIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.
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S-EPMC12485675 | biostudies-literature
UnknownNovel Molecular Signatures in the PIP4K/PIP5K Family of Proteins Specific for Different Isozymes and Subfamilies Provide Important Insights into the Evolutionary Divergence of this Protein Family.
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S-EPMC6523245 | biostudies-literature
ProteomicsPIP4kγ is a substrate for mTORC1
Phosphatidylinositol-5-phosphate 4-kinases (PIP4ks) are a family of lipid kinases that specifically use PI-5-P as a substrate to synthesize PI-4,5-P2. Suppression of PIP4k function in Drosophila results in smaller cells and reduced target of rapamycin complex 1 (TORC1) signaling. We showed that the ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-05-04 | PXD001340 | Pride
Mtorc1 Phossphatidylinositol-5-phosphate 4-kinase Pip4kγ Phosphoinositide Pip4k 
TranscriptomicsEffect of PIP4Ks on gene expression and alternative splicing levels in U2OS cells
Here we report the function of PIP4K isoforms in differential gene expression in physiological and UV conditions. Our data indicate that PIP4K2A knockdown adversely affects UV-induced gene expression and alternative splicing which is rescued by simultanous knockdown of PIP4K2B.
ORGANISM(S): Homo sapiens 
2021-12-08 | GSE189651 | GEO
UnknownPhosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling.
Not available
S-EPMC6591132 | biostudies-literature
UnknownPI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase.
Not available
S-EPMC10267561 | biostudies-literature
UnknownPIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity.
Not available
S-EPMC8346797 | biostudies-literature
TranscriptomicsDual Blockade of the Lipid Kinase PIP4Ks and Mitotic Pathways Leads to Cancer-selective Lethality
We discover drugs with a dual-inhibitory mechanism provides a unique pharmacological strategy against cancer and evidence of cross-activation between the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways via a Ras˧PIK3IP1˧PI3K signaling network Achieving robust cancer-specific lethality is the ultimate cli...
ORGANISM(S): Homo sapiens 
2018-02-23 | GSE104301 | GEO
ProteomicsProteome profiling of PIP4K depleted cells
Phosphatidylinositol-5-phosphate 4-kinases (PIP4Ks) family include PIP4K2A, PIP4K2B and PIP4K2C isoforms that phosphorylate phosphatidylinositol-5-phosphate on fourth position of inositol ring and catalyse PtdIns(4,5)P2 formation. These enzymes are central to cellular processes such as growth and de...
ORGANISM(S): Homo Sapiens (human) 
2022-11-19 | PXD029802 | JPOST Repository
UnknownDual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.
Not available
S-EPMC5736559 | biostudies-literature
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