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TranscriptomicsTranscription profiling of diagnostic tumoral samples in relation to primary response to drug treatment
Expression profile of diagnostic tumoral samples in relation to primary response to drug treatment
ORGANISM(S): Homo sapiens 
2005-10-30 | E-MEXP-388 | biostudies-arrayexpress
TranscriptomicsMicroarray expression of B-cell Non-Hodgkins Lymphoma cases
Transcriptional profiling of major types of B-cell NHL clinical samples. While comparing all the types together, their expression was compared against reactive lymph nodes, except SMZL whose expression was compared against normal splenic cells. Keywords: disease state analysis Clinical samples; 8 re...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9327 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by the pan-PIM inhibitor ETP-39010 in 4 peripheral T cell lymphoma cell lines
Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. In these study we hypothesized that PIM kinases could be of therapeutic value in PTCL because we ...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-42595 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of BRCA1-mutated breast tumors
Background: Breast cancer is a complex disease, encompassed by different clinically and molecularly stratified entities. In 2000, Perou and colleagues demonstrated that tumor phenotypic diversity correlates with differences in global gene expression patterns, which in turn reflect aspects of the bio...
ORGANISM(S): Homo sapiens 
2009-10-14 | E-GEOD-12350 | biostudies-arrayexpress
TranscriptomicsGene-expression profile in a series of non-Hodgkin lymphoma (NHL) patients
PIM serine/threonine kinases are overexpressed, translocated or amplified in multiple B-cell lymphoma types. We have explored the frequency and relevance of PIM expression in different B-cell lymphoma types, and investigated whether PIM inhibition could be a rational therapeutic approach. Increased ...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-32018 | biostudies-arrayexpress
TranscriptomicsFollicular lymphoma in situ and partial involvement by follicular lymphoma are clona lesions that carry the t(14;18) and lack genetic secondary alterations
Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21), frequent numerical chromosomal alterations, and recurrent somatic mutations. However, no genetic studies are available for FL in situ (FLIS), a putative precursor lesion of FL. In this study, we analyzed cases of FLIS without manife...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-48548 | biostudies-arrayexpress
TranscriptomicsMolecular characterization of the chromosome 7 in SMZL
Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin’s lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have loc...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-31203 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human peripheral T cell lymphoma cases vs. reactive lymph nodes
Peripheral T cell lymphoma (PTCL) is a very aggressive disease which currently lacks efficient targeted therapy. New therapeutic strategies are needed to improve the very poor outcome of these patients. However, little is known about the molecular pathogenesis of this disease. In this study, we perf...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-36172 | biostudies-arrayexpress
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (CGH)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35367 | biostudies-arrayexpress
UnknownDNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features.
Not available
S-EPMC4416938 | biostudies-literature
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