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MetabolomicsIdentification of amniotic fluid metabolomic and placental transcriptomic changes associated with abnormal development of cloned pig fetuses
Piglets cloned by somatic cell nuclear transfer (SCNT) show a high incidence of malformations and a high death rate during the perinatal period. To investigate the underlying mechanisms for abnormal development of cloned pig fetuses, we compared body weight, amniotic fluid (AF) metabolome, and place...
2020-01-08 | MTBLS666 | MetaboLights
TranscriptomicsEffects of moderate ethanol consumption during pregnancy on placental gene expression
We conducted a preliminary investigation to determine whether ethanol-induced alterations in placental gene expression may have some utility as a diagnostic indicator of maternal drinking during pregnancy as well as a prognostic indicator of risk for adverse neurobehavioral outcomes in affected offs...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-18162 | biostudies-arrayexpress
ProteomicsMultiomics reveals placental defect underlying preeclampsia
Preeclampsia is a serious pregnancy-induced disorder unique to humans affecting 4.6% of pregnancies worldwide. Advances in the detection, prevention and treatment of preeclampsia have been poor due to our inadequate understanding of its pathogenesis. Here, we perform a multiomics study on early preg...
ORGANISM(S): Homo sapiens (Human) 
2026-06-10 | PXD059993 | Pride
Multiomics Preeclampsia Placental defects Placenta Cvs 
GenomicsDefects in placental syncytiotrophoblast cells are a common cause of developmental heart disease
Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease
PRJNA842571 | ENA
ProteomicsComparative analysis of the human and mouse placental transcriptome and proteome
An important question for the use of the mouse as a model for studying human disease is the degree of functional conservation of genetic control pathways from human to mouse. The human and mouse placenta show structural similarities but there have been no systematic attempt to assess their molecular...
ORGANISM(S): Mus musculus 
2009-06-29 | E-GEOD-13299 | biostudies-arrayexpress
UnknownSecondary Placental Defects in Cxadr Mutant Mice.
Not available
S-EPMC6628872 | biostudies-literature
TranscriptomicsMicroarray analysis of gene expression profiles in Map2k1+/-Map2k2+/- and Map2k1flox/-Map2k2+/-Tg+/Sox2Cre placentas
The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and Map2k2, encoding dual-specificity kinases responsible for ERK/MAP kinase activation. Loss of Map2k1 function in mouse causes embryonic lethality due to placental defects, while Map2k2 mutant mice survive with a normal lifespan...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-51644 | biostudies-arrayexpress
UnknownCongenital Heart Disease Fetuses Have Decreased Mid-Gestational Placental Flow, Placental Malperfusion Defects, and Impaired Growth.
Not available
S-EPMC11786062 | biostudies-literature
TranscriptomicsDefects in placental syncytiotrophoblast cells are a common cause of developmental heart disease
E14.5 placentas from three mutant mutant mouse lines (Atp11a, Smg9 and Ssr2) with high co-occurance of placental and heart defects were sequenced. Transcriptional changes associated with ventricular septal defects were characterized.
ORGANISM(S): Mus musculus 
2023-02-01 | GSE204859 | GEO
TranscriptomicsE12.5 CD9+ Mouse Placental Trophoblast Microarray, Wild-type vs c-Met KO
The placenta serves as the structural interface for nutrient and waste exchange for proper fetal development. Although defects in placental function result in various placental disorders, molecular mechanisms orchestrating placental development and function are poorly understood. Gene targeting stud...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-38342 | biostudies-arrayexpress
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