Sort   by:  
 Page size 
ProteomicsLung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy
Treatment of lung adenocarcinomas (LUAD) that exhibit activated epidermal growth factor receptor (EGFR) with EGFR tyrosine kinase inhibitors (TKI) has limited efficacy. Assessment of the impact of EGFR TKI on the LUAD surfaceome remodeling revealed potential therapeutic targets. We identified placen...
ORGANISM(S): Homo sapiens (Human) 
2025-10-09 | PXD069074 | Pride
Placental type alkaline phosphatase Egfr tyrosine kinase inhibitors Antibody drug conjugate Egfr tki resistance Lung adenocarcinomas Combinational therapy 
TranscriptomicsRegulatory role of multinucleated giant cells derived from placental CD14+ macrophages: Pathophysiological implications
The role of placental macrophages is largely ignored in the success of pregnancy. We found that CD14+ macrophages purified from at-term placentas spontaneously matured into multinucleated giant cells (MGCs). MGCs lost the expression of CD14 and co-inhibitory molecules, such as Programmed cell Death-...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-38747 | biostudies-arrayexpress
TranscriptomicsPlacental gene expression in severe preeclampsia.
The series is composed of thirty hybridizations for analysis of differentially expressed genes in normal placenta tissues from patients with normal labor and placenta tissues from patients with severe preeclampsia. Patients tissues samples were obtained from (Vasilis. Total RNA extraction was perfor...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10588 | biostudies-arrayexpress
TranscriptomicsEffect of fetal HDL on gene expression in human placental endothelial cells
The aim of this study was to identify HDL and apoE-regulated genes in human placental endothelial cells (HPEC), which are exposed to fetal HDL. HPECs extracted from 5 human placentas were cultivated and treated for 16 h with 15ug/ml fetal HDL, 15ug/ml reconstituted HDL (rHDL), or endothelial basal m...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-MEXP-3299 | biostudies-arrayexpress
UnknownLung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy.
Not available
S-EPMC12765945 | biostudies-literature
UnknownHuman placental alkaline phosphatase as a tracking marker for bone marrow mesenchymal stem cells.
Not available
S-EPMC3776624 | biostudies-literature
UnknownThe effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells.
Not available
S-EPMC2646593 | biostudies-literature
TranscriptomicsWhole-transcriptome profiling analysis of first trimester placental villi in Indian women
Whole-transcriptome profiles of individual human placental villi samples from twenty-five (25) Indian women with normal pregnancies during 6- to 8-weeks of gestation were examined using human whole genome expression arrays (NimbleGen 135K). The present study focused on the whole-transcriptome profil...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-37653 | biostudies-arrayexpress
TranscriptomicsDietary heme mediated PPARM-NM-1 activation does not affect the heme-induced epithelial hyperproliferation and hyperplasia in mouse colon
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is overcompensated by hyperproliferation and hyperplasia of crypt cells. Transcriptome anal...
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-37006 | biostudies-arrayexpress
TranscriptomicsPlacental infection single-cell and single-nuclei maps
This resource comprises a single-cell multi-lineage map of first trimester infected placental cells. We have included data from both uninfected cells and cells infected with three pathogens known to cause maternal and fetal disorders: Plasmodium falciparum, Listeria monocytogenes, and Toxoplasma gon...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-12795 | biostudies-arrayexpress
Sort   by:  
 Page size