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MetabolomicsThe glycosyltransferase UGT76B1 modulates N-hydroxy-pipecolic acid homeostasis and plant immunity
The trade-off between growth and defense is a critical aspect of plant immunity. Therefore, the plant immune response needs to be tightly regulated. Salicylic acid (SA) is an important plant hormone regulating defense against biotrophic pathogens. Recently, N-hydroxy-pipecolic acid (NHP) was identif...
2022-02-28 | MTBLS2334 | MetaboLights
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
MetabolomicsThe Streptomyces-derived nucleoside Guvermectin simultaneously promotes plant growth and immunity

This study investigates the dual role of the Streptomyces-derived nucleoside Guvermectin (GV) in promoting plant growth and enhancing disease resistance. Multiomics analysis revealed that GV reprograms phenylalanine metabolism, leading to the accumulation of antimicrobial flavonoids. A key UDP-gl...

2026-01-31 | MTBLS13810 | MetaboLights
MetabolomicsOsWRKY39 regulates phenylpropanoid metabolic reprogramming to orchestrate rice immunity against Magnaporthe oryzae

Magnaporthe oryzae threatens global rice production, but master regulators coordinating immunity, metabolism, and growth remain elusive. Here, we identify OsWRKY39 as a central hub integrating blast resistance, phenylpropanoid metabolism, hormone homeostasis, and growth-defense trade-offs, distin...

2025-12-05 | MTBLS13460 | MetaboLights
MetabolomicsPlant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens
Rice is a staple food crop worldwide, and its production is severely threatened by phloem-feeding insect herbivores, particularly the brown planthopper (BPH, Nilaparvata lugens), and destructive pathogens. Despite the identification of many BPH resistance genes, the molecular basis of rice resistanc...
2022-02-23 | MTBLS3518 | MetaboLights
MetabolomicsIntegrated metabolomics and transcriptome revealed the effect of fermented Lycium barbarum residue promoting Ovis aries immunity
Lycium barbarum residue contains abundant bioactive nutrients which can be used as feed supplement. This study investigated the effects of fermented and non-fermented Lycium barbarum residues (RFW and RW) on the meat quality and immunity of sheep (Ovis aries). Fifty-four Tan sheep were randomly divi...
2022-04-06 | MTBLS4507 | MetaboLights
ProteomicsThe Nα-acetyltransferase NAA50 mediates plant immunity independent of the NatA complex
Nα-terminal acetylation (NTA) ranges among the most abundant protein modifications in higher eukaryotes. Over 40 % of the human and plant proteome are co-translationally acetylated by a single Nα-acetyltransferase (Nat) termed NatA. The core NatA complex consists of the catalytic subunit NAA10 and t...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-03-01 | PXD040755 | JPOST Repository
MetabolomicsGhPsbO breaks the growth-immunity trade-off by simultaneously promoting growth and defence
The evolutionarily conserved trade-off between pathogen resistance and crop yield remains a major bottleneck in agricultural breeding. Although numerous genes governing disease resistance or growth productivity have been identified, the pleiotropic regulatory factors that harmonize these two agronom...
2026-04-29 | MTBLS14410 | MetaboLights
MetabolomicsDiurnal Dynamics Shape Plant Defense Responses: Temporal Variations in Disease Progression and Metabolic Reprogramming in Brassica oleracea
Plants synchronize their immune responses with the circadian cycle, yet the impact of diurnal timing on disease resistance remains poorly understood in crop species. In this study, we investigated how diurnal variation modulates defense responses in Brassica oleracea against Xanthomonas campestris p...
2025-08-22 | MTBLS7854 | MetaboLights
ProteomicsThe protein interactomes of AtNHR2A and AtNHR2B unraveled common and specialized functions in plant immunity integrating distinct biological processes
AtNHR2A (Arabidopsis thaliana nonhost resistance 2A) and AtNHR2B (Arabidopsis thaliana nonhost resistance 2B) are two proteins required in nonhost resistance, a broad spectrum mechanism of plant immunity that protects plants against pathogens. AtNHR2A and AtNHR2B are localized to the cytoplasm, chlo...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-03-10 | PXD015894 | Pride
Affinity purification Arabidopsis Mass spectrometry Co-immunoprecipitation Plant immunity 
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