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ProteomicsSpatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis
Lipids play a crucial role in signalling and metabolism, regulating the development and maintenance of the skeleton. Membrane lipids have been hypothesised to act as intermediates upstream of orphan phosphatase 1 (PHOSPHO1), a major contributor to phosphate generation required for bone mineralisatio...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-19 | PXD038909 | Pride
Mouse Maldi-ims Phospho1 Matrix mineralisation Disorders of calcium or phosphate metabolism Lipids Knee joint Growth plate Bone modelling and remodelling 
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
Embryonic stem (ES) cells were differentiated in culture to midbrain dopaminergic (mDA) progenitors and subjected to ChIP-seq analysis to resolve genome-wide binding sites of forkhead box protein A2 (Foxa2). Foxa2 was found to directly regulate multiple lineage pathways to specify midbrain dopaminer...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MTAB-1137 | biostudies-arrayexpress
TranscriptomicsGenetic regulation of gene expression of barley in response to stem rust (Pgt isolate TTKS)
The QxSM doubled-haploid mapping population was generated from a single Q21861 x SM89010 F1 plant (Borovkova et al. 1995; Steffenson et al. 1995). Four flats (each flat contained 75 DH lines + 4 replicates of each parent = 81 cones/flat) were grown in a completely randomized design at the ARS Cereal...
ORGANISM(S): Hordeum vulgare 
2010-11-15 | E-GEOD-20416 | biostudies-arrayexpress
UnknownThe heterogeneous mechanical properties of adolescent growth plate cartilage: A study in rabbit.
Not available
S-EPMC9047008 | biostudies-literature
TranscriptomicsExpression data for Lck-Cre, Med23flox/flox and Med23flox/flox;Lck-Cre thymocytes +/- 3hr exposure to plate bound anti-CD3 antibody
MED23, a subunit of the Mediator coactivator complex, is important for the expression of a subset of MAPK/ERK pathway-dependent target genes; however, the genes in this subset varies between cell types. MAPK/ERK pathway-dependent processes are essential for T-cell development and function, but whet...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-57061 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken proliferative and hypertrophic chondrocytes
Longitudinal bone growth depends upon the execution of an intricate series of cellular activities by epiphyseal growth plate chondrocytes. In order to better understand these coordinated events, microarray analysis was used to compare gene expression in chondrocytes isolated from the proliferative a...
ORGANISM(S): Gallus gallus 
2009-10-23 | E-GEOD-18568 | biostudies-arrayexpress
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
TranscriptomicsTranscriptional profiling analysis of pre-selected DP thymocytes in response to positive and negative selection signals
Sustained Ca2+ entry into CD4+CD8+ double-positive thymocytes is required for positive selection. We identified a voltage-gated Na+ channel (VGSC), essential for positive selection of CD4+ T cells. Pharmacological inhibition of VGSC activity inhibited sustained Ca2+ influx induced by positive-select...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-38909 | biostudies-arrayexpress
UnknownA zone-plate-based two-color spectrometer for indirect X-ray absorption spectroscopy.
Not available
S-EPMC6613121 | biostudies-literature
ProteomicsQuantitative LC-MS/MS analysis of secretome of Mesenchymal Cells from Tooth Germ of Mice
Label free: The aim of project is to identify the proteins that may have a role in the inductive signal of mesenchymal cells.   Protein identification and quantitively compare the proteins from the following samples: 1- Exosomes purified from embryonic mesenchymal cells of tooth germ after overnigh...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053767 | Pride
Tandem mass tagging Mouse Secretome Orbitrap fusion lumos Lc-ms/ms 
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