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ProteomicsThe platelet releasate in healthy population and pregancy
Upon activation, platelets release a multitude of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). This PR plays an important role in haemostasis, wound healing and the inflammatory response. We and others have used qualitative/quantitative proteomic approaches to ch...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-29 | MSV000082866 | MassIVE
ProteomicsThe platelet releasate in healthy population and pregancy
Upon activation, platelets release a multitude of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). This PR plays an important role in haemostasis, wound healing and the inflammatory response. We and others have used qualitative/quantitative proteomic approaches to ch...
ORGANISM(S): Homo sapiens (Human) 
2018-06-25 | PXD009310 | Pride
Human Platelets Platelet releasate Pregnancy Lc-ms/ms 
ProteomicsComparative platelet releasate proteome profiling of acute coronary syndrome versus stable coronary artery disease
Upon activation, platelets release a host of soluble and vesicular signals, collectively termed the ‘platelet releasate’ (PR). The contents of this PR play a significant role in haemostasis, inflammation, and pathologic sequelae. Despite this, proteomic studies investigating the PR in coronary arter...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD009356 | Pride
Platelet releasate Proteomics Platelets Acute coronary syndrome Stable coronary artery disease Lc-ms/ms 
ProteomicsUltra-sensitive platelet proteome maps the O-glycosylation landscape and identifies a new form of domain-specific O-fucosylation
Platelet activation induces the secretion of proteins that promote platelet aggregation and inflammation. However, detailed analysis of the released platelet proteome is hampered by platelets’ tendency to pre-activate during their isolation and a lack of sensitive protocols for low abundance releasa...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD045535 | Pride
O-glycosylation Platelet 
Proteomicsplatelet hyperreactivity project
The aim of this study is to identify candidate genes modulating platelet reactivity in aspirin-treated cardiovascular patients using an integrative network-based approach. Platelet reactivity was assessed in 110 cardiovascular patients treated with aspirin 100mg/d by aggregometry using several agoni...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD001861 | Pride
Releasate Secretory granules Cardiovascular patients Aspirin Network biology High platelet reactivity Platelets 
ProteomicsThe platelet releasate (PR) in human pregnancy
Healthy pregnancy is characterized by an increase in platelet activation and a decrease in the number of circulating platelets with gestation. Despite this recognised importance, proteomic studies investigating platelets in healthy pregnancy have not been performed. As platelet cargo can be altered...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD009361 | Pride
Platelet releasate Pregnancy Mass spectrometry Platelets Label-free quantitation 
GenomicsMicrovascular Endothelial Cell RNA-Seq: Treatment with Platelet Releasate from COVID-19 & Control Donors
Microvascular Endothelial Cell RNA-Seq: Treatment with Platelet Releasate from COVID-19 & Control Donors
PRJNA736408 | ENA
ProteomicsCharacterisation of Platelet Releasate Proteome in Relapsing-Remitting Multiple Sclerosis Reveals Dysregulation of Inflammatory Signalling and Extracellular Vesicle Dynamics
Multiple Sclerosis is an inflammatory neurodegenerative disease characterised by blood-brain barrier dysfunction and leukocyte infiltration into the central nervous system. Platelets are best known for their contributions to haemostasis, however upon activation platelets release an abundance of solu...
ORGANISM(S): Homo sapiens (Human) 
2025-01-09 | PXD050479 | Pride
Multiple sclerosis Platelet releasate 
ProteomicsIdentification of SEC61B as a novel regulator of calcium flux and platelet hyperactivity in diabetes mellitus
Platelet hyperactivity contributes to increased cardiovascular thrombosis in diabetes. Intracellular and released proteins control platelet activity however there are limited proteomic studies of the diabetic platelet. We isolated platelets from 34 patients without, and 42 patients with type 2 diabe...
ORGANISM(S): Homo sapiens (Human) 
2025-04-19 | PXD049321 | Pride
Sec61b Calcium Er stress Diabetes Translocon Platelet 
ProteomicsEndoplasmic reticulum protein 5 (ERp5) attenuates platelet endoplasmic reticulum stress and secretion in a mouse model
Extracellular protein disulphide isomerases (PDIs) are required for in vivo thrombus formation in mice. Platelets secrete ~10% of their PDIs upon activation, including PDI, endoplasmic reticulum protein 57 (ERp57), ERp72, ERp46 and ERp5, which promote platelet aggregation. However the role of intrac...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-13 | PXD034094 | Pride
Platelets Erp5 Mouse 
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