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TranscriptomicsRNA-seq of human neutrophil-like cell line PLB-985 at various stages of differentiation with CRISPR knock-outs of H1 linker histones
Finding that PLB-985 knockouts of H1.2 or H1.4 were deficient in their differentiation to neutrophil-like cells, we decided to perform RNA-seq on 2 single-cell clones of knockouts of each of the linker histones H1.1-H1.5.
ORGANISM(S): Homo sapiens 
2020-05-11 | E-MTAB-8459 | biostudies-arrayexpress
TranscriptomicsRNA-microarray analysis of PLB-985 cells cultured with or without interferon-gamma under both conditions that induce or do not induce cell differentiation
Interferon-gamma (IFN-gamma) is approved as a drug to treat chronic granulomatous disease and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. These primary immunodeficiencies involve defects in neutrophils/polymorphonuclear cells. Neutrophils mature in the bone marrow and then e...
ORGANISM(S): Homo sapiens 
2017-08-31 | E-MTAB-5690 | biostudies-arrayexpress
ProteomicsDifferentiated PLB-985 cells as a model system for Aspergillus fumigatus infection
Fungal infections remain a tremendous source of global morbidity and mortality, with more than 1 billion individuals affected by fungal infections each year. Invasive infections are particularly dangerous and kill numbers on par with tuberculosis or malaria. Aspergillus fumigatus is a major source o...
ORGANISM(S): Aspergillus fumigatus CEA10 Homo sapiens (Human) 
2021-07-30 | PXD027032 | Pride
Extracellular vesicle Aspergillus fumigatus Plb-985 cells Size-exclusion chromatography Lc-ms/ms 
UnknownPLB-985 Neutrophil-Like Cells as a Model To Study Aspergillus fumigatus Pathogenesis.
Not available
S-EPMC8730815 | biostudies-literature
UnknownMembrane Dynamics and Organization of the Phagocyte NADPH Oxidase in PLB-985 Cells.
Not available
S-EPMC7751761 | biostudies-literature
GenomicsRNA-seq of human neutrophil-like cell line PLB-985 at various stages of differentiation with CRISPR knock-outs of H1 linker histones
RNA-seq of human neutrophil-like cell line PLB-985 at various stages of differentiation with CRISPR knock-outs of H1 linker histones
PRJEB35046 | ENA
UnknownA study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.
Not available
S-EPMC10035560 | biostudies-literature
UnknownImmunoblotting validation of research antibodies generated against HS1-associated protein X-1 in the human neutrophil model cell line PLB-985.
Not available
S-EPMC4893944 | biostudies-literature
ProteomicsQuantifying changes in the bacterial thiol redox proteome during host-pathogen interaction
In this study, we used a quantitative redox proteomic method (OxICAT) to assess the in vivo thiol oxidation status of phagocytized E. coli. The majority (65.5%) of identified proteins harbored thiols that were significantly oxidized (>30%) upon phagocytosis. A substantial number of these proteins ar...
ORGANISM(S): Escherichia coli 
2019-01-07 | PXD011386 | Pride
Plb-985 Neutrophils Escherichia coli Redox proteomics 
UnknownNeutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation.
Not available
S-EPMC10849234 | biostudies-literature
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