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ProteomicsStructural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation
The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity towards lipids or endo- and exonuclease activity towards nucleic acids. PLD3 is synthesized as a type II transmembrane protein and proteolytically cleaved in lysosomes yielding a soluble active form. The deficien...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-24 | PXD044504 | Pride
Lysosome Phospholipase d Structural biology Dna/rna degradation 5' exonuclease Pld3 
ProteomicsAMPylation Regulates 5'-3' Exonuclease PLD3 processing
The 5’-3’ exonuclease phospholipase D3 (PLD3) is a type II transmembrane protein undergoing sequential post-translational modifications (PTM) by N-glycosylation, AMPylation and proteolytic cleavage. The substrates of PLD3 5’-3’ exonuclease activity are single-stranded DNAs and RNAs, which act as lig...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD057707 | Pride
Pld3 Ampylation Chemical proteomics Protein post-translational modifications 
GenomicsPLD3 and PLD4 limit autoinflammation through multiple sensors of RNA and DNA.
PLD3 and PLD4 limit autoinflammation through multiple sensors of RNA and DNA.
PRJNA757361 | ENA
UnknownAMPylation Regulates 5'-3' Exonuclease PLD3 Processing.
Not available
S-EPMC12494813 | biostudies-literature
UnknownPLD3 epigenetic changes in the hippocampus of Alzheimer's disease.
Not available
S-EPMC6134774 | biostudies-literature
TranscriptomicsPLD3 and PLD4 limit autoinflammation through multiple sensors of RNA and DNA.
Supplementary Figure 14. RNAseq analysis of Pld3–/–Pld4–/– liver. Poly A+ RNA from whole livers were compared using next generation sequencing and the genes showing significant differences in expression from control livers of age-matched mice were further analyzed.
ORGANISM(S): Mus musculus 
2021-08-25 | GSE182648 | GEO
UnknownPLD3 is accumulated on neuritic plaques in Alzheimer's disease brains.
Not available
S-EPMC4255636 | biostudies-literature
UnknownThe p53/ZEB1-PLD3 feedback loop regulates cell proliferation in breast cancer.
Not available
S-EPMC10656518 | biostudies-literature
ProteomicsConcerted action of RNase T2 and PLD exonucleases in RNA processing for TLR7 activation
Toll-like receptor 7 (TLR7) plays a key role in the recognition of RNA viruses and the subsequent induction of an innate immune response. TLR7 contains two ligand binding pockets that recognize distinct RNA degradation products: Pocket 1 recognizes guanosine nucleotides and pocket 2 coordinates shor...
ORGANISM(S): Homo sapiens (Human) 
2024-06-19 | PXD045912 | Pride
Toll-like receptor Proteomics Nuclease Lc-ms/ms 
UnknownPLD3 affects axonal spheroids and network defects in Alzheimer's disease.
Not available
S-EPMC9729106 | biostudies-literature
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