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ProteomicsStructural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation
The phospholipase D (PLD) family is comprised of enzymes bearing phospholipase activity towards lipids or endo- and exonuclease activity towards nucleic acids. PLD3 is synthesized as a type II transmembrane protein and proteolytically cleaved in lysosomes yielding a soluble active form. The deficien...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-24 | PXD044504 | Pride
Lysosome Phospholipase d Structural biology Dna/rna degradation 5' exonuclease Pld3 
ProteomicsAMPylation Regulates 5'-3' Exonuclease PLD3 processing
The 5’-3’ exonuclease phospholipase D3 (PLD3) is a type II transmembrane protein undergoing sequential post-translational modifications (PTM) by N-glycosylation, AMPylation and proteolytic cleavage. The substrates of PLD3 5’-3’ exonuclease activity are single-stranded DNAs and RNAs, which act as lig...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD057707 | Pride
Pld3 Ampylation Chemical proteomics Protein post-translational modifications 
ProteomicsPLD3 and PLD4 synthesize lysosomal S,S-BMP
LD3 knock out cells were generated in HEK293T and HMC3 cells. Proteomics was done to test if they have any significant changes in the abundance of proteins that metabolize sugar lipids like gangliosides.
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD046505 | Pride
Pld3 lysosomes Microglia 
UnknownPLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes.
Not available
S-EPMC10983895 | biostudies-literature
UnknownAMPylation Regulates 5'-3' Exonuclease PLD3 Processing.
Not available
S-EPMC12494813 | biostudies-literature
UnknownStructural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation.
Not available
S-EPMC10783504 | biostudies-literature
UnknownPLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
Not available
S-EPMC8031396 | biostudies-literature
ProteomicsPLD3 and PLD4 synthesize lysosomal S,S-BMP
This part of the data submission of PXD046505. LD3 knock out cells were generated in HEK293T and HMC3 cells. Proteomics was done to test if they have any significant changes in the abundance of proteins that metabolize sugar lipids like gangliosides.
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD057372 | Pride
Pld3 lysosomes Microglia 
TranscriptomicsLysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Autophagy targets a wide variety of substrates for degradation within lysosomes. Although lysosomes are known to possess RNase activity, the role of lysosomal RNA degradation in post-transcriptional gene regulation is not well understood. We defined RNASET2, PLD3, and both endogenous and exogenous R...
ORGANISM(S): Homo sapiens 
2025-12-08 | GSE296736 | GEO
UnknownPhospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism.
Not available
S-EPMC10209153 | biostudies-literature
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