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ProteomicsUnbiased identification of Pleiotrophin-interacting proteins in the brain
Affinity purification-mass spectrometry was performed to identify proteins associated with pleiotrophin in wild-type mouse brain tissue. Ptn and hFc control pulldowns were analyzed to identify specific Ptn-interacting proteins.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-21 | PXD081065 | Pride
Pleiotrophin  mouse brain 
MetabolomicsMetabolomics-driven identification of biochemical mechanisms underlying the neuroprotective effects of pleiotrophin in a mouse model of Parkinson’s disease
Not available
ORGANISM(S): Mus musculus 
ST001810 | MetabolomicsWorkbench
TranscriptomicsGene expression profiles of Glioblastoma stem cells in which ALK or pleiotrophin expression was suppressed.
Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells. Anaplastic lymphoma kinase (ALK) and its ligand pleiotrophin are required for maintaining the stem-lik...
ORGANISM(S): Homo sapiens 
2011-09-30 | E-GEOD-32482 | biostudies-arrayexpress
TranscriptomicsNeural Precursor Cell-Derived Pleiotrophin Mediates Glioma Invasion of the Subventricular Zone
The lateral ventricle subventricular zone (SVZ) is a frequent and consequential site of pediatric and adult glioma spread, but the cellular and molecular mechanisms mediating this are poorly understood. We demonstrate that neural precursor cell (NPC):glioma cell communication underpins this propensi...
ORGANISM(S): Homo sapiens 
2017-07-26 | GSE99812 | GEO
GenomicsPleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment
Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment
PRJNA824490 | ENA
UnknownPleiotrophin regulates the expansion and regeneration of hematopoietic stem cells.
Not available
S-EPMC3689427 | biostudies-literature
UnknownElevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus.
Not available
S-EPMC5522313 | biostudies-literature
UnknownNeural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.
Not available
S-EPMC5587159 | biostudies-literature
TranscriptomicsTranscription profiling of rat ureteric buds treated with either heregulin, pleiotrophin or conditioned medium from metanephric mesenchymal cell culture
Genes ontologically classified as proliferative and developmental were down-regulated by HRG, whereas those involved in transport were up-regulated. For example, the mRNA for the GDNF receptors, GFRa1 and ret9 were down-regulated while the mRNA for collecting duct transporters, such as urea transpor...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-3394 | biostudies-arrayexpress
UnknownA Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ.
Not available
S-EPMC2936342 | biostudies-literature
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