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ProteomicsThe plasma membrane localization of PLEKHA5 is regulated by the phosphorylation status of S161
The phosphorylation of PLEKHA5 serine 161 residue affects the subcellular localization of the protein. Mutations of this site led to changes in plasma mebrane association during mitosis. The IP-MS experiment was conducted to confirm the phosphorylation at S161.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD052237 | Pride
Phosphorylation Mitosis Plekha5 Plasma membrane 
GenomicsExpression profile of 58As9 cells upon PLEKHA5 knockdown
Expression profile of 58As9 cells upon PLEKHA5 knockdown
PRJNA684583 | ENA
TranscriptomicsExpression profile of 58As9 cells upon PLEKHA5 knockdown
Phosphoproteomic analysis of diffuse-type gastric carcinoma cells with Met gene amplification identified Pleckstrin Homology Domain Containing A5 (PLEKHA5) as a protein that is tyrosine-phosphorylated downstream of Met. We used DNA microarray analysis to explore the signaling pathways downstream of ...
ORGANISM(S): Homo sapiens 
2020-12-12 | GSE163063 | GEO
ProteomicsThe disturbance of lipid metabolism by the TNF-α /PLEKHA5/FCRLA axis leads to the proliferation, invasion and metastasis of cutaneous malignant melanoma
Background: Cutaneous malignant melanoma (CMM) is one of the most highly fatal cancers; its pathogenesis requires study. We recognize that abnormalities in lipid metabolism may be associated with the risk of CMM development; nevertheless, the role of lipid metabolism in the proliferation, invasion, ...
ORGANISM(S): Homo Sapiens 
PXD054835 |
UnknownPLEKHA5 regulates tumor growth in metastatic melanoma.
Not available
S-EPMC7147081 | biostudies-literature
UnknownPLEKHA5 as a Biomarker and Potential Mediator of Melanoma Brain Metastasis.
Not available
S-EPMC4397107 | biostudies-literature
UnknownPLEKHA5 regulates the survival and peritoneal dissemination of diffuse-type gastric carcinoma cells with Met gene amplification.
Not available
S-EPMC7936979 | biostudies-literature
UnknownSingle-cell transcriptomics and functional validation revealed PLEKHA5-L as a promoter of growth and migration in brain metastatic melanoma cells.
Not available
S-EPMC12066752 | biostudies-literature
UnknownWW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7.
Not available
S-EPMC8458771 | biostudies-literature
UnknownCharacterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor.
Not available
S-EPMC7519681 | biostudies-literature
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