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In many organisms, the circadian clock is composed of functionally coupled morning and evening oscillators that regulate the bouts of dawn and dusk activity. In Arabidopsis, oscillator coupling relies on a core loop in which the evening oscillator component TOC1 was proposed to activate a subset of ...
ORGANISM(S): Arabidopsis thaliana 
This model is from the article: The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops Pokhilko A, Fernández AP, Edwards KD, Southern MM, Halliday KJ, Millar AJ. Mol Syst Biol.2012 Mar 6;8:574. 22395476, Abs...
2024-09-02 | BIOMD0000000412 | BioModels
Pokhilko2013 - TOC1 signalling in Arabidopsis circadian clock In this model, Pokhilko et al. has incorporated the negative transcriptional regulations of the core clock genes by TOC1 and the up-regulation of TOC1 expression by ABA signalling, to their previous model BIOMD0000000412 ...
2024-09-02 | BIOMD0000000445 | BioModels
This a model from the article: Data assimilation constrains new connections and components in a complex, eukaryotic circadian clock model. Pokhilko A, Hodge SK, Stratford K, Knox K, Edwards KD, Thomson AW, Mizuno T, Millar AJ. Mol Syst Biol.2010 Sep 21;6:416. 2...
2024-09-02 | BIOMD0000000273 | BioModels
The extracellular matrix (ECM), a key interface between the cerebrovasculature and other cells within the neuro-glial-vascular unit , provides structural stability and modulates cell behaviour and signalling. These functions are dependent on ECM protein composition. Since ECM defects may contribute ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-03-11 | PXD020436 | Pride
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