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UnknownReduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters.
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S-EPMC11229363 | biostudies-literature
GenomicsTotal RNA Pol2 ChIP-seq in mES cells treated with flavopiridol (Cdk9 inhibitor) after DSIF and NELF knockdown
Recent studies have found that promoter-proximal pausing occurs at most Pol2-regulated genes. DSIF and NELF function as negative elongation factors and promote Pol2 pausing. P-TEFb, whose enzymatic activity lies in the kinase Cdk9, positively regulates the transition into productive elongation by ...
ORGANISM(S): Mus musculus 
2011-01-19 | E-GEOD-26658 | biostudies-arrayexpress
GenomicsReduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [GRO-seq]
Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [GRO-seq]
PRJNA1007637 | ENA
ProteomicsReduction of ZFX levels decreases histone H4 acetylation and increases the pause ratio at target promoters
The ZFX transcriptional activator binds to CpG island promoters, with a major peak at ~200-250bp downstream from transcription start sites. Because ZFX binds within the transcribed region, we investigated whether it regulates transcriptional elongation. We used GRO-seq to show that loss or reduction...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044709 | Pride
Elongation Turboid Pol2 pausing Zfx Transcription 
GenomicsTotal RNA Pol2 ChIP-seq in mES cells treated with flavopiridol (Cdk9 inhibitor) after DSIF and NELF knockdown
Recent studies have found that promoter-proximal pausing occurs at most Pol2-regulated genes. DSIF and NELF function as negative elongation factors and promote Pol2 pausing. P-TEFb, whose enzymatic activity lies in the kinase Cdk9, positively regulates the transition into productive elongation by ph...
ORGANISM(S): Mus musculus 
2011-01-19 | GSE26658 | GEO
TranscriptomicsMapping Replication Fork Pause Sites in S. cerevisiae
Replication forks face multiple obstacles that slow their progression. By two-dimensional gel analysis, yeast forks pause at stable DNA protein complexes, and this pausing is greatly increased in the absence of the Rrm3 helicase. We used a genome wide approach to identify 96 sites of very high DNA p...
ORGANISM(S): Saccharomyces cerevisiae 
2009-06-15 | E-GEOD-16218 | biostudies-arrayexpress
GenomicsReduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [ChIP-Seq]
Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [ChIP-Seq]
PRJNA1007617 | ENA
GenomicsReduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [RNA-Seq]
Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters [RNA-Seq]
PRJNA1007634 | ENA
GenomicsReduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters
Reduction of ZFX levels decreases histone H4 acetylation and increases Pol2 pausing at target promoters
PRJNA1007628 | ENA
GenomicsFork Pausing Complex Engages Topoisomerases at the Replisome
Fork Pausing Complex Engages Topoisomerases at the Replisome
PRJNA588062 | ENA
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